Molecular structure of Phenformin Hydrochloride, CAS Number: 834-28-6
Phenformin Hydrochloride (CAS 834-28-6)
See product citations (4)
Alternate Names:
Phenethylbiguanide; N-(2-Phenylethyl)imidodicarbonimidic diamide monohydrochloride
Application:
Phenformin Hydrochloride is an AMPK activator used in cardiology studies
CAS Number:
834-28-6
Molecular Weight:
241.72
Molecular Formula:
C10H15N5•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Phenformin Hydrochloride is utilized in studying cellular metabolism and energy production. It affects the function of mitochondria, the powerhouses of the cell, by inhibiting complex I of the electron transport chain. This inhibition leads to a decrease in ATP production and an increase in AMP-activated protein kinase activity. Phenformin Hydrochloride is known to activate the LKB1-AMPK pathway, which plays a role in regulating cellular energy homeostasis. It induces apoptosis in certain cancer cell lines by disrupting energy metabolism. Phenformin Hydrochloride is for studying the molecular mechanisms of cellular energy regulation.
Phenformin Hydrochloride (CAS 834-28-6) References
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- Determination of metformin in plasma using a new ion pair solid phase extraction technique and ion pair liquid chromatography. | AbuRuz, S., et al. 2003. J Chromatogr B Analyt Technol Biomed Life Sci. 798: 203-9. PMID: 14643498
- Molecularly imprinted solid-phase extraction for the screening of antihyperglycemic biguanides. | Feng, SY., et al. 2004. J Chromatogr A. 1027: 155-60. PMID: 14971497
- Determination of phenformin hydrochloride using molecular imprinting technology coupled with flow-injection chemiluminescence. | Liu, Z., et al. 2012. Luminescence. 27: 297-301. PMID: 21990141
- [Effect of phenformin hydrochloride on pharmacokinetics of puerarin in rats]. | Deng, Y., et al. 2012. Zhongguo Zhong Yao Za Zhi. 37: 2960-3. PMID: 23270242
- Phenformin-loaded polymeric micelles for targeting both cancer cells and cancer stem cells in vitro and in vivo. | Krishnamurthy, S., et al. 2014. Biomaterials. 35: 9177-86. PMID: 25106770
- [Rapid screening and quantitative detection of 11 illegally added antidiabetics in health care products by ultra performance liquid chromatography-quadrupole/electrostatic field orbitrap high resolution mass spectrometry]. | Du, Y., et al. 2015. Se Pu. 33: 371-6. PMID: 26292406
- Highly sensitive on-site detection of drugs adulterated in botanical dietary supplements using thin layer chromatography combined with dynamic surface enhanced Raman spectroscopy. | Fang, F., et al. 2016. Talanta. 146: 351-7. PMID: 26695274
- Two-Step Centrifugation Method for Subpicomolar Surface-Enhanced Raman Scattering Detection. | Shi, Y., et al. 2016. Anal Chem. 88: 5009-15. PMID: 27064074
- FTY720 inhibits the activation of pancreatic stellate cells by promoting apoptosis and suppressing autophagy via the AMPK/mTOR pathway. | Cui, L., et al. 2019. Life Sci. 217: 243-250. PMID: 30550889
- Highly sensitive detection of an antidiabetic drug as illegal additives in health products using solvent microextraction combined with surface-enhanced Raman spectroscopy. | Li, P., et al. 2019. Analyst. 144: 7406-7411. PMID: 31670319
- Saikosaponin A inhibits the activation of pancreatic stellate cells by suppressing autophagy and the NLRP3 inflammasome via the AMPK/mTOR pathway. | Cui, L., et al. 2020. Biomed Pharmacother. 128: 110216. PMID: 32497863
- STAT1 potentiates oxidative stress revealing a targetable vulnerability that increases phenformin efficacy in breast cancer. | Totten, SP., et al. 2021. Nat Commun. 12: 3299. PMID: 34083537
Inhibitor of:
AKR1B8, AMPKβ2, AMPKγ1, APPL2, BCAT2, biotinidase, CARKL, CDKAL1, FAHD1, G3PP, GK3P, GLYATL3, GTPBP3, LACE1, LRP130, MCCA, MCT4, MDH1B, MO25, NDUFA4L2, NDUFS, PDPR, PTRH2, RFESD, SIK2, SLC43A3, Tim17B, Uqcr, and ZAG.Activator of:
ADPGK, AMPK, AMPKα1, AMPKα2, ATPIF1, CAB39L, CHCHD1, CNDP2, collectrin, DAK, DLST, eIF3α, FNIP1, G6PT, GlcNAc kinase, Glut14, GNPDA1, GRB10, H6PD, HISPPD1, IDHC, LARS2, LDH-AL6A, LDH-AL6B, LDHA, LDHB, MFSD6L, NDRG3, Ribosomal Protein L14, Snf1, TMPRSS11A, and UCK2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Phenformin Hydrochloride, 10 g | sc-219590 | 10 g | $117.00 |