Phenformin hydrochloride is a hydrochloride salt of the biguanidine drug phenformin that displays anti-diabetic activity. It has been shown to increase AMPK activity without increasing AMP/ATP activity. It has been shown, however, that treating hearts with phenformin hydrochloride and then perfusing with Krebs-Henseleit buffer increases AMPK and AMP activity and also elevates phosphorylated acetyl-CoA carboxylase.
Moody, J.E., Anal. Profiles Drug Subs., 4, 319 (1975)
Soluble in water (50 mg/ml), ethanol (12 mg/ml at 25° C), methanol, and DMSO (48 mg/ml at 25° C).
Store at -20° C
n20D ~1.62 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Deng Y;et alDeng Y;et al. (PubMed ID: 23270242) demonstrated that Phenformin hydrochloride can slow down the absorption activity of puerarin and may change the pharmacokinetic process of puerarin in rats. -SCBT Publication Review
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