Phenformin Hydrochloride CAS: 834-28-6
MF: C10H15N5•HCl
MW: 241.72
An AMPK activator used in cardiology studies.

Phenformin Hydrochloride (CAS 834-28-6)

Phenformin Hydrochloride | CAS 834-28-6 is rated 5.0 out of 5 by 1.
  • y_2020, m_8, d_13, h_15
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.10
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_219590, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 128ms
  • REVIEWS, PRODUCT
5
1
4
0
3
0
2
0
1
0
Alternate Names: Phenethylbiguanide; N-(2-Phenylethyl)imidodicarbonimidic diamide monohydrochloride
Application: Phenformin Hydrochloride is an AMPK activator used in cardiology studies
CAS Number: 834-28-6
Molecular Weight: 241.72
Molecular Formula: C10H15N5•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Phenformin hydrochloride is a hydrochloride salt of the biguanidine drug phenformin that displays anti-diabetic activity. It has been shown to increase AMPK activity without increasing AMP/ATP activity. It has been shown, however, that treating hearts with phenformin hydrochloride and then perfusing with Krebs-Henseleit buffer increases AMPK and AMP activity and also elevates phosphorylated acetyl-CoA carboxylase.


References

Moody, J.E., Anal. Profiles Drug Subs., 4, 319 (1975)

Appearance :
Crystalline
Physical State :
Solid
Solubility :
Soluble in water (50 mg/ml), ethanol (12 mg/ml at 25° C), methanol, and DMSO (48 mg/ml at 25° C).
Storage :
Store at -20° C
Melting Point :
175-178° C
Density :
1.26 g/cm3
Refractive Index :
n20D ~1.62 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
DU2200000
PubChem CID :
13266
Merck Index :
14: 7231
MDL Number :
MFCD00035039
EC Number :
212-637-3
SMILES :
Cl.NC(=N)NC(=N)NCCC1=CC=CC=C1

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Phenformin Hydrochloride (CAS 834-28-6)  Product Citations

See how others have used Phenformin Hydrochloride (CAS 834-28-6). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 30893014  Kast, DJ.|Dominguez, R.| et al. 2019. Mol. Biol. Cell. 30: 1285-1297.

Citations 1 to 1 of 1 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 111ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Deng Y;et al Deng Y;et al. (PubMed ID: 23270242) demonstrated that Phenformin hydrochloride can slow down the absorption activity of puerarin and may change the pharmacokinetic process of puerarin in rats. -SCBT Publication Review
Date published: 2015-07-03
  • y_2020, m_8, d_13, h_15
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.10
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_219590, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 11ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.