Chemical activators of SLC26A10 include a diverse array of compounds that can enhance the protein's function through various biochemical pathways. Forskolin is known to activate adenylate cyclase, which leads to an increase in cAMP levels within the cell. This rise in cAMP can activate protein kinase A (PKA) and other cAMP-responsive elements that can phosphorylate SLC26A10, thereby increasing its transporter activity. Similarly, IBMX, a non-selective inhibitor of phosphodiesterases, prevents the breakdown of cAMP, thus sustaining elevated levels of this messenger that contribute to the activation of SLC26A10. The compound Dibutyryl-cAMP, a cell-permeable analog of cAMP, directly mimics the action of elevated cAMP and activates PKA, which then can phosphorylate and activate SLC26A10. Another compound, N6-Benzoyl-cAMP, selectively activates PKA and is likely to promote the activation of SLC26A10 through similar phosphorylation events.
In addition to pathways involving cAMP, other signaling molecules also play a role in the activation of SLC26A10. Genistein, a tyrosine kinase inhibitor, can alter phosphorylation patterns in cells, which may result in the enhanced activity of SLC26A10. PMA, which activates protein kinase C (PKC), and A23187, an ionophore that increases intracellular calcium, can both influence the phosphorylation state of proteins and may activate SLC26A10 indirectly through calcium-dependent or PKC-mediated signaling pathways. EGTA, by chelating extracellular calcium, might trigger intracellular signaling cascades that lead to the activation of SLC26A10 in an effort to compensate for altered calcium levels. Biochanin A modulates various kinase pathways, which could lead to the phosphorylation and subsequent activation of SLC26A10. LY294002, while primarily a PI3K inhibitor, can cause upregulation of compensatory regulatory mechanisms within the cell, which may include the activation of SLC26A10 through alternative signaling pathways. Lastly, Clofilium Tosylate, by blocking potassium channels, may induce cellular mechanisms to maintain ion balance, including the activation of SLC26A10, as a response to the changes in ion homeostasis. Each of these chemicals, through their unique interactions with cellular signaling pathways, can contribute to the activation of SLC26A10, underlining the multifaceted regulation of this protein.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
3,5-Diiodo-L-thyronine | 1041-01-6 | sc-216601 sc-216601A sc-216601B sc-216601C sc-216601D | 1 g 5 g 10 g 25 g 100 g | $270.00 $562.00 $938.00 $1408.00 $2673.00 | 2 | |
Binds to thyroid hormone receptors which can affect the transcription of genes involved in ion transport, potentially enhancing SLC26A10 activity through upregulation of associated transport machinery. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
Non-selective inhibitor of phosphodiesterases which increases intracellular cAMP, potentially leading to the phosphorylation and activation of SLC26A10. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Tyrosine kinase inhibitor that can indirectly lead to the activation of SLC26A10 by altering phosphorylation patterns that govern transporter activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Activates protein kinase C which is involved in the regulation of transporter proteins and may activate SLC26A10 through phosphorylation. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
Ionophore that increases intracellular calcium concentration, thereby potentially activating SLC26A10 through calcium-dependent signaling pathways. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Cell-permeable cAMP analog that activates cAMP-dependent pathways, possibly leading to the activation of SLC26A10 through phosphorylation events. | ||||||
Biochanin A | 491-80-5 | sc-205603 sc-205603A | 100 mg 250 mg | $77.00 $132.00 | ||
A natural isoflavone that modulates various kinase pathways, potentially enhancing the activity of SLC26A10 through phosphorylation. | ||||||
EGTA | 67-42-5 | sc-3593 sc-3593A sc-3593B sc-3593C sc-3593D | 1 g 10 g 100 g 250 g 1 kg | $21.00 $65.00 $120.00 $251.00 $815.00 | 23 | |
Chelates extracellular calcium, possibly leading to compensatory mechanisms that activate calcium-sensing pathways involved in SLC26A10 regulation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A PI3K inhibitor that might upregulate compensatory regulatory mechanisms, leading to SLC26A10 activation through alternate signaling routes. | ||||||
Clofilium tosylate | 92953-10-1 | sc-391228 sc-391228A | 25 mg 100 mg | $437.00 $1040.00 | 1 | |
Potassium channel blocker that may lead to changes in cellular ion homeostasis, potentially activating SLC26A10 as part of the cell's response to maintain ion balance. | ||||||