Biochanin A, an isoflavone, is a natural plant phytoestrogen which has been reported to be an antiproliferative and anti-inflammatory agent. Studies show that this compound inhibits iNOS expression and lipopolysacharide (LPS)-induced nitric oxide production in macrophages. Additionally, Biochanin A displays the ability to block phosphorylation of IκBα and p38 MAPK, which prevents NF-κB activation. Furthermore, Biochanin A has been observed to suppress IL-6, IL-1β, and TNF-α production.
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Can you provide the references for the IC50 data listed for Biochanin A?
Asked by: ChemSynth123
Thank you for your question.
Here are some citations for Biochanin A, sc-205603, IC50 data:
12/21/2016: IC50 values were pulled from https://www.ebi.ac.uk/chembl/bioactivity/results/1/cmpd_chemblid/asc/tab/display.
J. Med. Chem. (2000) 43:4169-4179 - https://www.ebi.ac.uk/chembl/doc/inspect/CHEMBL1133504
J. Med. Chem. (2008) 51:4188-4199 - https://www.ebi.ac.uk/chembl/doc/inspect/CHEMBL1157467
J. Nat. Prod. (2006) 69:43-49 - https://www.ebi.ac.uk/chembl/doc/inspect/CHEMBL1157220
J. Nat. Prod. (2000) 63:1414-1416 - https://www.ebi.ac.uk/chembl/doc/inspect/CHEMBL1155607
J. Med. Chem. (2006) 49:3345-3353 - https://www.ebi.ac.uk/chembl/doc/inspect/CHEMBL1148505
Rated 5 out of
WangWang, J. et al. (PubMed 26394281) reported that Biochanin A protects dopaminergic neurons against lipopolysaccharide-induced damage and oxidative stress in a rat model of Parkinson's disease. -SCBT Publication Review
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