Molecular structure of Biochanin A, CAS Number: 491-80-5
Biochanin A (CAS 491-80-5)
Alternate Names:
5,7-Dihydroxy-4′-methoxyisoflavone; 4′-Methylgenistein
Application:
Biochanin A is a nitric oxide synthase inhibitor and apoptosis inducer
CAS Number:
491-80-5
Purity:
≥98%
Molecular Weight:
284.27
Molecular Formula:
C16H12O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Biochanin A, an isoflavone, is a natural plant phytoestrogen which has been reported to be an antiproliferative and anti-inflammatory agent. Studies show that this compound inhibits iNOS expression and lipopolysacharide (LPS)-induced nitric oxide production in macrophages. Additionally, Biochanin A displays the ability to block phosphorylation of IkappaBalpha and p38 MAPK, which prevents NF-kappaB activation. Furthermore, Biochanin A has been observed to suppress IL-6, IL-1beta, and TNF-alpha production.
Biochanin A (CAS 491-80-5) References
- The mitochondrial monoamine oxidase-aldehyde dehydrogenase pathway: a potential site of action of daidzin. | Rooke, N., et al. 2000. J Med Chem. 43: 4169-79. PMID: 11063613
- Antigiardial activity of isoflavones from Dalbergia frutescens bark. | Khan, IA., et al. 2000. J Nat Prod. 63: 1414-6. PMID: 11076565
- Effects of synthetic and naturally occurring flavonoids on metabolic activation of benzo[a]pyrene in hamster embryo cell cultures. | Chae, YH., et al. 1992. Chem Biol Interact. 82: 181-93. PMID: 1568269
- Isoflavonoids and other compounds from Psorothamnus arborescens with antiprotozoal activities. | Salem, MM. and Werbovetz, KA. 2006. J Nat Prod. 69: 43-9. PMID: 16441066
- Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. | Tasdemir, D., et al. 2006. J Med Chem. 49: 3345-53. PMID: 16722653
- Discovery of nonsteroidal 17beta-hydroxysteroid dehydrogenase 1 inhibitors by pharmacophore-based screening of virtual compound libraries. | Schuster, D., et al. 2008. J Med Chem. 51: 4188-99. PMID: 18533708
- Biochanin A, a naturally occurring inhibitor of fatty acid amide hydrolase. | Thors, L., et al. 2010. Br J Pharmacol. 160: 549-60. PMID: 20590565
- Biochanin-A, an isoflavon, showed anti-proliferative and anti-inflammatory activities through the inhibition of iNOS expression, p38-MAPK and ATF-2 phosphorylation and blocking NFκB nuclear translocation. | Kole, L., et al. 2011. Eur J Pharmacol. 653: 8-15. PMID: 21147093
- Biochanin A attenuates myocardial ischemia/reperfusion injury through the TLR4/NF-κB/NLRP3 signaling pathway. | Bai, Y., et al. 2019. Acta Cir Bras. 34: e201901104. PMID: 31859817
- Biochanin A: A novel bioactive multifunctional compound from nature. | Sarfraz, A., et al. 2020. Sci Total Environ. 722: 137907. PMID: 32208265
- Biochanin A Alleviates Cerebral Ischemia/Reperfusion Injury by Suppressing Endoplasmic Reticulum Stress-Induced Apoptosis and p38MAPK Signaling Pathway In Vivo and In Vitro. | Guo, MM., et al. 2021. Front Endocrinol (Lausanne). 12: 646720. PMID: 34322090
- Biochanin A alleviates cognitive impairment and hippocampal mitochondrial damage in ovariectomized APP/PS1 mice. | Hou, Y., et al. 2022. Phytomedicine. 100: 154056. PMID: 35338989
- Biochanin A as a modulator of the inflammatory response: An updated overview and therapeutic potential. | Felix, FB., et al. 2022. Pharmacol Res. 180: 106246. PMID: 35562014
- Structural requirements for differentiation-induction and growth-inhibition of mouse erythroleukemia cells by isoflavones. | Jing, Y. and Waxman, S. 1995. Anticancer Res. 15: 1147-52. PMID: 7653993
Inhibitor of:
ACSL, ACSL4, ERRγ, FAM123A, FOXE2, RFT1, SGLT-3, SLC43A1, SULT2B10, UGT1A6B, UGT2B37, and UGT2B5.Activator of:
β-catenin, Cdx1, Chibby, CUT, DAAM1, Dlx-5, ER beta, ERRα, FAM123A, FAM174B, FGF-6, FOXD3, FOXI3, FRAT1, frizzled-3, KRTAP16-10, NKD1, Oct-4, p120, Pbx 1, PDGFR-B, POP-1, R-Spondin2, R-Spondin3, R-Spondin4, RTP1, Sall1, SLC26A10, Sox-15, TTBK2, Vangl2, Wnt-15, ZNF414, and ZNF434.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Biochanin A, 100 mg | sc-205603 | 100 mg | $75.00 | |||
Biochanin A, 250 mg | sc-205603A | 250 mg | $129.00 |