Six5 Activators
"SIX homeobox 5" often abbreviated as "SIX5," is a gene that plays a crucial role in human biology and genetics. It belongs to a group of genes known as the SIX family, which are characterized by the presence of a homeobox, a DNA sequence that encodes for a particular type of protein domain known as the homeodomain. This homeodomain allows proteins produced by SIX genes to bind to DNA and function as transcription factors, influencing the expression of other genes.
SIX5 is particularly notable for its involvement in developmental processes. During embryonic development, it plays a significant role in the formation and differentiation of various tissues and organs. The protein encoded by SIX5 is involved in the regulation of other genes that are critical for normal development, particularly in the eyes, muscles, and certain glands.Mutations in the SIX5 gene have been associated with various medical conditions. One of the most notable is its link to Branchio-Oto-Renal (BOR) syndrome, a rare genetic disorder characterized by developmental abnormalities in the neck, ears, and kidneys. This association underscores the gene's importance in embryonic development and tissue formation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin indirectly activates SIX5 by elevating cAMP levels, which can affect transcriptional regulation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, a polyphenol in green tea, might modulate SIX5 activity through its influence on DNA methylation and histone modification. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
As a histone deacetylase inhibitor, Trichostatin A can affect transcription factors like SIX5 by altering chromatin structure. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
This DNA methyltransferase inhibitor can indirectly influence SIX5 by altering the epigenetic landscape. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Involved in gene expression modulation, Retinoic Acid could indirectly affect SIX5 activity through transcriptional regulation. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
As an inhibitor of MEK, PD98059 might indirectly impact SIX5 function via the MAPK signaling pathway. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
By inhibiting PI3K, LY294002 can affect pathways that potentially modulate SIX5 activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
This mTOR inhibitor might influence SIX5 activity indirectly through key signaling pathways. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
As an inhibitor of TGF-β type I receptor, SB431542 can influence transcription factors and might affect SIX5. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $43.00 $65.00 $200.00 $815.00 | 6 | |
As a form of vitamin B3, Nicotinamide can affect gene expression and might influence SIX5. | ||||||