SIK1 Inhibitors
SIK1 inhibitors belong to a class of chemical compounds designed to selectively target and inhibit Salt-Inducible Kinase 1 (SIK1), a protein kinase that plays a crucial role in various cellular processes. These inhibitors are molecular entities engineered to modulate the activity of SIK1, a member of the SIK family of serine/threonine kinases. SIK1 itself is involved in regulating key biological functions, particularly in response to external stimuli and stressors. By specifically blocking the enzymatic activity of SIK1, these inhibitors disrupt the downstream signaling pathways and cellular processes controlled by SIK1, which can have significant implications in various areas of research.
Inhibitors of SIK1 typically function by binding to the kinase's active site, preventing its interaction with its substrate molecules. This blockade results in a reduction or cessation of SIK1-mediated phosphorylation reactions, ultimately impacting the cellular processes regulated by SIK1. These processes include gene expression, immune response modulation, and metabolic regulation. Researchers utilize SIK1 inhibitors as valuable tools in cell biology and molecular biology studies to dissect the intricate signaling pathways in which SIK1 is involved.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
A potent, non-selective inhibitor of protein kinases, staurosporine may inhibit SIK1 activity as part of its broad kinase inhibition profile. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $42.00 $62.00 $153.00 $255.00 $500.00 $30.00 | 37 | |
1,1-Dimethylbiguanide, Hydrochloride can inhibit mTOR signaling, which may secondarily decrease SIK1 expression. | ||||||
5-Iodotubercidin | 24386-93-4 | sc-3531 sc-3531A | 1 mg 5 mg | $150.00 $455.00 | 20 | |
A potent adenosine kinase inhibitor that can also inhibit other kinases including SIK1 by blocking ATP utilization. | ||||||
Sodium dichloroacetate | 2156-56-1 | sc-203275 sc-203275A | 10 g 50 g | $54.00 $205.00 | 6 | |
Dichloroacetate, by shifting metabolism from glycolysis to glucose oxidation, could influence SIK1 expression indirectly. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $56.00 $260.00 $416.00 | 129 | |
Sorafenib inhibits several tyrosine protein kinases, potentially affecting SIK1 activity or expression. | ||||||
Arcyriaflavin A | 118458-54-1 | sc-202470 sc-202470A sc-202470B | 1 mg 10 mg 100 mg | $152.00 $292.00 $1796.00 | 4 | |
A cyclin-dependent kinase inhibitor that may have off-target effects on kinases like SIK1 due to its structure. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
A flavonoid with antioxidant properties, quercetin can modulate various signaling pathways, possibly impacting SIK1 expression. | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $92.00 $182.00 | 71 | |
H-89 is known to inhibit Protein Kinase A, and through intricate signaling networks, it may influence SIK1 activity. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $92.00 $260.00 | 42 | |
Also known as Seliciclib, it inhibits cyclin-dependent kinases and might reduce SIK1 expression as a secondary effect. | ||||||
LY2228820 | 862507-23-1 | sc-364525 | 5 mg | $191.00 | 1 | |
This compound is a p38 MAPK inhibitor and may have a role in downregulating SIK1 through the MAPK signaling pathway. | ||||||