LY2228820 (CAS 862507-23-1)
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SB 202190 is a p38 MAP (mitogen activated protein) Kinase inhibitor with an IC50 of 7 nm. LY2228820 inhibits lipopolysaccharide (LPS)-induced TNFα formation in murine peritoneal macrophages, with IC50 of 5.2 nM. In multiple myeloma (MM) cells, LY2228820 significantly blocks p38MAPK signaling, as revealed by its inhibition on phosphorylation of HSP27, a downstream target of p38MAPK, without affecting the expression level of HSP27. LY2228820 enhances bortezomib-induced cytotoxicity and apoptosis, but it alone doesn′t inhibit the growth of MM.1S cells. LY2228820 also inhibits secretion of IL-6 and MIP-1α in long-term BM stromal cells (LT-BMSCs), BM mononuclear cells (BMMNCs), peripheral blood (PB) CD138+, CD138− or PB CD14+ cells. LY2228820 also blocks osteoclastogenesis from CD14+ cells.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LY2228820, 5 mg | sc-364525 | 5 mg | $191.00 |