Molecular structure of Arcyriaflavin A, CAS Number: 118458-54-1
Arcyriaflavin A (CAS 118458-54-1)
See product citations (4)
Application:
Arcyriaflavin A is a potent inhibitor of CDK4/cyclin D1
CAS Number:
118458-54-1
Purity:
≥95%
Molecular Weight:
325.30
Molecular Formula:
C20H11N3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Arcyriaflavin A is a potent inhibitor of CDK4/cyclin D1 (IC50 = 59nM). It inhibits human cytomegalovirus (HCMV) replication in cell culture (IC50 = 200nM). Arcyriaflavin A is also a CaMKII inhibitor. Arcyriaflavin A, a natural polyether compound, exhibits cytotoxic properties against cancer cells. It is found in endometrial tissue. Additionally, it hinders the interaction between growth factors and their receptors or other cell surface proteins involved in cell signaling pathways. These effects may arise from its capacity to enhance reactive oxygen species production and inhibit protein synthesis by preventing the phosphorylation of eIF2α.
Arcyriaflavin A (CAS 118458-54-1) References
- Indolocarbazoles: potent, selective inhibitors of human cytomegalovirus replication. | Slater, MJ., et al. 1999. Bioorg Med Chem. 7: 1067-74. PMID: 10428375
- Open analogues of arcyriaflavin A. Synthesis through Diels-Alder reaction between maleimides and 1-aryl-3-tert-butyldimethylsiloxy-1, 3-butadienes. | Adeva, M., et al. 2000. J Org Chem. 65: 3387-94. PMID: 10843621
- Synthesis of quinolinyl/isoquinolinyl[a]pyrrolo [3,4-c] carbazoles as cyclin D1/CDK4 inhibitors. | Zhu, G., et al. 2003. Bioorg Med Chem Lett. 13: 1231-5. PMID: 12657252
- Aryl[a]pyrrolo[3,4-c]carbazoles as selective cyclin D1-CDK4 inhibitors. | Sanchez-Martinez, C., et al. 2003. Bioorg Med Chem Lett. 13: 3835-9. PMID: 14552791
- Two indolocarbazole alkaloids with apoptosis activity from a marine-derived actinomycete Z(2)039-2. | Liu, R., et al. 2007. Arch Pharm Res. 30: 270-4. PMID: 17424930
- Inhibition of ABCG2-mediated transport by protein kinase inhibitors with a bisindolylmaleimide or indolocarbazole structure. | Robey, RW., et al. 2007. Mol Cancer Ther. 6: 1877-85. PMID: 17575116
- Characterization and functional modification of StaC and RebC, which are involved in the pyrrole oxidation of indolocarbazole biosynthesis. | Asamizu, S., et al. 2011. Biosci Biotechnol Biochem. 75: 2184-93. PMID: 22056432
- Total Syntheses of Arcyriaflavin A and Calothrixin B Using 2,2'-Bisindole-3-acetic Acid Derivative as a Common Intermediate. | Lee, S., et al. 2017. Org Lett. 19: 2785-2788. PMID: 28520441
- Arcyriaflavin a, a cyclin D1-cyclin-dependent kinase4 inhibitor, induces apoptosis and inhibits proliferation of human endometriotic stromal cells: a potential therapeutic agent in endometriosis. | Hirakawa, T., et al. 2017. Reprod Biol Endocrinol. 15: 53. PMID: 28720098
- Brønsted Acid Catalyzed One-Pot Benzannulation of 2-Alkenylindoles under Aerial Oxidation: A Route to Carbazoles and Indolo[2,3- a]carbazole Alkaloids. | Saha, S., et al. 2018. Org Lett. 20: 6920-6924. PMID: 30358409
- Identification of a DNA Methylation-Driven Genes-Based Prognostic Model and Drug Targets in Breast Cancer: In silico Screening of Therapeutic Compounds and in vitro Characterization. | Tian, S., et al. 2021. Front Immunol. 12: 761326. PMID: 34745136
- Synergistic Anticancer Effect of a Combination of Berbamine and Arcyriaflavin A against Glioblastoma Stem-like Cells. | Han, JM. and Jung, HJ. 2022. Molecules. 27: PMID: 36432068
- Staurosporine aglycone (K252-c) and arcyriaflavin A from the marine ascidian, Eudistoma sp. | Horton, PA., et al. 1994. Experientia. 50: 843-5. PMID: 7925852
Inhibitor of:
CaMKII, Cdk4, CREB-2, cyclin D1, Ser/Thr Protein Kinase, SIK1, and TAFII-28.Activator of:
ZNF347.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Arcyriaflavin A, 1 mg | sc-202470 | 1 mg | $155.00 | |||
Arcyriaflavin A, 10 mg | sc-202470A | 10 mg | $298.00 | |||
Arcyriaflavin A, 100 mg | sc-202470B | 100 mg | $1832.00 |