Arcyriaflavin A CAS: 118458-54-1
MF: C20H11N3O2
MW: 325.3
A potent inhibitor of CDK4/cyclin D1.

Arcyriaflavin A (CAS 118458-54-1)

Arcyriaflavin A | CAS 118458-54-1 is rated 5.0 out of 5 by 1.
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Application: Arcyriaflavin A is a potent inhibitor of CDK4/cyclin D1
CAS Number: 118458-54-1
Purity: ≥95%
Molecular Weight: 325.3
Molecular Formula: C20H11N3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Arcyriaflavin A is a potent inhibitor of CDK4/cyclin D1 (IC50 = 59nM). It inhibits human cytomegalovirus (HCMV) replication in cell culture (IC50 = 200nM). Arcyriaflavin A is also a CaMKII inhibitor.


References

1. Horton, P.A., et al. 1994. Experientia. 50: 843-845. PMID: 7925852
2. Slater, M.J., et al. 1999. Bioorg. Med. Chem. 7: 1067-1074. PMID: 10428375
3. Sanchez-Martinez, C., et al. 2003. Bioorg. Med. Chem. Lett. 13: 3835-3839. PMID: 14552791
4. Zhu, G., et al. 2003. Bioorg. Med. Chem. Lett. 13: 1231-1235. PMID: 12657252
5. Liu, R., et al. 2007. Arch. Pharm. Res. 30: 270-274. PMID: 17424930

Usage :
Stock solutions are stable for up to 3 months at -20°C. Whenever possible solutions should be made up and used on the same day.
Physical State :
Solid
Derived From :
Synthetic. Originally isolated from the marine ascidian Eudistoma sp.
Solubility :
Soluble in DMSO (100 mM).
Storage :
Store at -20° C
Melting Point :
300.41° C (Predicted)
Boiling Point :
687.98° C (Predicted)
Density :
1.62 g/cm3 (Predicted)
Refractive Index :
n20D 1.96 (Predicted)
IC50 :
human cytomegalovirus (HCMV) replication: IC50 = 200 nM; CaM kinase II: IC50 = 25 nM; CDK4 / cyclin D1: IC50 = 59 nM
pK Values :
pKa: 10.74 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5327726
MDL Number :
MFCD03452662
SMILES :
CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CN(C5=CC=CC=C54)CCCN(C)C

Download SDS (MSDS)

Certificate of Analysis

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Arcyriaflavin A (CAS 118458-54-1)  Product Citations

See how others have used Arcyriaflavin A (CAS 118458-54-1). Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 28720098  Hirakawa, T. et al. 2017. Reprod. Biol. Endocrinol. 15: 53.

PMID: # 30451834  Cell Death Dis. 1147.

PMID: # 31160361  Infect. Immun. 87:

Citations 1 to 3 of 3 total
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Rated 5 out of 5 by from Slater et al Slater et al. (PubMed ID 10428375) found that Arcyriaflavin A inhibited human cytomegalovirus (HCMV) replication. -SCBT Publication Review
Date published: 2015-04-23
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