Molecular structure of 5-Iodotubercidin, CAS Number: 24386-93-4
5-Iodotubercidin (CAS 24386-93-4)
See product citations (20)
Alternate Names:
5-Iodo-7-β-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidin-4- amine
Application:
5-Iodotubercidin is a potent and competitive inhibitor of ERK 2, PKA, and ADK
CAS Number:
24386-93-4
Purity:
≥98%
Molecular Weight:
392.15
Molecular Formula:
C11H13IN4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
5-Iodotubercidin is a chemical compound also known as 5-ITu or 5-iodo-7-[(1R,2R,3R,4S)-3,4-dihydroxy-2-(hydroxymethyl)cyclopentyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine, it is a selective inhibitor of adenosine kinase, an enzyme involved in the metabolism of adenosine. Researchers utilize 5-Iodotubercidin to investigate the role of adenosine kinase and adenosine signaling pathways in various biological processes. By inhibiting adenosine kinase, this compound can modulate the levels of adenosine, an important endogenous signaling molecule involved in diverse physiological and pathological processes.
5-Iodotubercidin (CAS 24386-93-4) References
- Adenosine kinase inhibitors. 1. Synthesis, enzyme inhibition, and antiseizure activity of 5-iodotubercidin analogues. | Ugarkar, BG., et al. 2000. J Med Chem. 43: 2883-93. PMID: 10956196
- Effects of 5-iodotubercidin on hepatic fatty acid metabolism mediated by the inhibition of acetyl-CoA carboxylase. | García-Villafranca, J. and Castro, J. 2002. Biochem Pharmacol. 63: 1997-2000. PMID: 12093476
- Identification of 5-Iodotubercidin as a genotoxic drug with anti-cancer potential. | Zhang, X., et al. 2013. PLoS One. 8: e62527. PMID: 23667485
- Inhibitory effect of 5-iodotubercidin on pigmentation. | Kim, KI., et al. 2017. Biochem Biophys Res Commun. 490: 1282-1286. PMID: 28684314
- Crystal structure of ADP-dependent glucokinase from Methanocaldococcus jannaschii in complex with 5-iodotubercidin reveals phosphoryl transfer mechanism. | Tokarz, P., et al. 2018. Protein Sci. 27: 790-797. PMID: 29352744
- 5'-Iodotubercidin represses insulinoma-associated-1 expression, decreases cAMP levels, and suppresses human neuroblastoma cell growth. | Chen, C., et al. 2019. J Biol Chem. 294: 5456-5465. PMID: 30755485
- Haspin-dependent and independent effects of the kinase inhibitor 5-Iodotubercidin on self-renewal and differentiation. | Karanika, E., et al. 2020. Sci Rep. 10: 232. PMID: 31937797
- 5-Iodotubercidin inhibits SARS-CoV-2 RNA synthesis. | Zhao, J., et al. 2022. Antiviral Res. 198: 105254. PMID: 35101534
- 5-Iodotubercidin Inhibits the Growth of Insulinoma Cells by Inducing Apoptosis. | Zheng, B., et al. 2023. Neuroendocrinology.. PMID: 36758529
- Identification of the glycogenic compound 5-iodotubercidin as a general protein kinase inhibitor. | Massillon, D., et al. 1994. Biochem J. 299 (Pt 1): 123-8. PMID: 8166629
- The adenosine kinase inhibitor, 5-iodotubercidin, is not protective against cerebral ischemic injury in the gerbil. | Phillis, JW. and Smith-Barbour, M. 1993. Life Sci. 53: 497-502. PMID: 8341136
- Stimulation of rat liver glycogen synthesis by the adenosine kinase inhibitor 5-iodotubercidin. | Flückiger-Isler, RE. and Walter, P. 1993. Biochem J. 292 (Pt 1): 85-91. PMID: 8503865
- A single amino acid substitution makes ERK2 susceptible to pyridinyl imidazole inhibitors of p38 MAP kinase. | Fox, T., et al. 1998. Protein Sci. 7: 2249-55. PMID: 9827991
Inhibitor of:
14-3-3 ζ, ADAT3, ADCK2, ADK, AK8, ART3, ART4, BIN2, C12orf50_1700017N19Rik, C12orf63, C16orf65, C430003P19Rik, C6orf199, Casein Kinase, CC2D2A, CDP2, cGKII, CLK1, CLK2, CMPK2, COASTER, CROP, DBX2, DDX34, Dyrk2, EG635895, ERK 2, FAM160A1, FANK1, Fus3, GAK, GCN2, GDNF, Gm355, Gm711, GMD, GPATCH1, GPN3, GUK1, HIPK1, HIPK3, HIPK4_Hipk4, HISPPD1, IGHMBP2, insulin R, IP6K2, KIAA0701, Kinesin, KKIALRE, KPRP, LOC388259, Nim1, NT5DC3, Nuak1, Nucleoside Monophosphate Kinase, Paip1, PAP-2c, PASK, PCBP4, PHPT1, PKA, PSD-93, PSK2, PTPN21, PTPy, RPRD2, Rslcan-8, RY1, SART-3, SENP3, Ser/Thr Protein Kinase, SIK1, SMEK2, SOX (SRY-box transcription factor), Sox-10, SOX15, TAGAP1, Talanin, TID-1L, TNNI3K, TSSK 3, TTBK1, TTBK2, UCK1, ULK3, ULK4, VRK1, VRK3, Wee 2, ZC3H14, and ZC3H4.Activator of:
2810403A07Rik, ABAT, Clik1, CLK3, CLK4, DRAK2, Dyrk4, EG628475, FAM75A3, FAM75C1, FAM75D4, INCENP, KIF26A, MAD1, Neuron navigator 3, NuMA, Olr1433, Olr1462, Olr1472, Olr1488, Olr150, Olr1513, Olr1517, Olr1520, Olr153, Olr1546, Olr1558, Olr1560, Olr1562, Olr1567, PHF23, PRP4 kinase, RNMT, SPRYD3, SPT7L, SRp30c, SRrp35, STG, TLK1, TMCC2, Tropomyosin β, ubiquitous kinesin heavy chain, XTP3TPA, and ZNF81.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5-Iodotubercidin, 1 mg | sc-3531 | 1 mg | $150.00 | |||
5-Iodotubercidin, 5 mg | sc-3531A | 5 mg | $455.00 |