Date published: 2026-4-24

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Shank Antibodies

Santa Cruz Biotechnology provides a broad selection of Shank monoclonal antibodies for advanced research in neuroscience and cellular biology. Shank monoclonal antibodies are validated for multiple applications, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Shank proteins play a crucial role in the organization of synapses and are essential for proper neuronal signaling and communication. Shank proteins contribute to the regulation of synaptic strength and plasticity, which are fundamental processes for learning and memory. Dysregulation of Shank proteins has been implicated in several neurodevelopmental disorders, making Shank proteins significant targets for research aimed at understanding these conditions. Researchers can utilize Shank monoclonal antibodies to investigate synaptic organization and function in various experimental models. Understanding Shank protein expression patterns helps reveal their role in both normal brain development and pathological conditions. Shank monoclonal antibodies from Santa Cruz Biotechnology enable researchers worldwide to advance our understanding of neurological disorders and potential therapeutic approaches.

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Shank Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

Shank 1 Antibody (E-1)

sc-398630mouse IgG1 κ1701-1830 (h)WB, IP, IF, ELISAm, r, h

new

(1)

Shank 1/2/3 Antibody (G-12)

sc-393963mouse IgG2a κ2124-2153 (h)WB, IP, IF, IHC(P), ELISAm, r, h
3
(2)

Shank 2 Antibody (A-11)

sc-271834mouse IgG1 κ996-1110 (h)WB, IP, IF, ELISAm, r, h
2
(5)

Shank 2 Antibody (B-4)

sc-365121mouse IgG2b κ996-1110 (h)WB, IP, IF, ELISAm, r, h
1
(2)

Shank 3 Antibody (C-4)

sc-377088mouse IgG1 κ1431-1590 (h)WB, IP, IF, ELISAm, r, h
8
(5)

Shank 3 Antibody (E-1)

sc-377470mouse IgG2a κ1431-1590 (h)WB, IP, IF, ELISAm, r, h
3
(4)

Shank CRISPR Knockout, HDR and Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

Shank 1 Double Nickase Plasmid (h)

sc-403064-NIChGene KnockoutPuromycin0
(0)

Shank 1 Double Nickase Plasmid (h2)

sc-403064-NIC-2hGene KnockoutPuromycin0
(0)

Shank 2 CRISPR/Cas9 KO Plasmid (h)

sc-403143hGene KnockoutGFP0
(0)

Shank 2 HDR Plasmid (h)

sc-403143-HDRhHomology Directed RepairPuromycin0
(0)

Shank2 CRISPR/Cas9 KO Plasmid (m)

sc-431686mGene KnockoutGFP0
(0)

Shank 3 CRISPR/Cas9 KO Plasmid (h)

sc-437313hGene KnockoutGFP0
(0)

Shank 3 HDR Plasmid (h)

sc-437313-HDRhHomology Directed RepairPuromycin0
(0)

Shank 3 CRISPR/Cas9 KO Plasmid (m)

sc-425500mGene KnockoutGFP0
(0)

Shank CRISPR Activation Products

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

Shank 1 CRISPR Activation Plasmid (h)

sc-403064-ACThGene ActivationPuro, Blast, Hygro0
(0)

Shank 1 CRISPR Activation Plasmid (h2)

sc-403064-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

Shank siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

Shank 1 siRNA (h)

sc-42196hGene SilencingN/A0
(0)

Shank 1 shRNA Plasmid (h)

sc-42196-SHhGene SilencingPuromycin0
(0)

Shank 1 shRNA (h) Lentiviral Particles

sc-42196-VhGene SilencingPuromycin0
(0)

Shank 1 siRNA (m)

sc-42197mGene SilencingN/A
1
(0)

Shank 1 shRNA Plasmid (m)

sc-42197-SHmGene SilencingPuromycin
1
(0)

Shank 1 shRNA (m) Lentiviral Particles

sc-42197-VmGene SilencingPuromycin
1
(0)

Shank 2 siRNA (h)

sc-42198hGene SilencingN/A0
(0)

Shank 2 shRNA Plasmid (h)

sc-42198-SHhGene SilencingPuromycin0
(0)

Shank 2 shRNA (h) Lentiviral Particles

sc-42198-VhGene SilencingPuromycin0
(0)

Shank 2 siRNA (m)

sc-42199mGene SilencingN/A0
(0)

Shank 2 shRNA Plasmid (m)

sc-42199-SHmGene SilencingPuromycin0
(0)

Shank 2 shRNA (m) Lentiviral Particles

sc-42199-VmGene SilencingPuromycin0
(0)

Shank 3 siRNA (h)

sc-42200hGene SilencingN/A0
(0)

Shank 3 shRNA Plasmid (h)

sc-42200-SHhGene SilencingPuromycin0
(0)

Shank 3 shRNA (h) Lentiviral Particles

sc-42200-VhGene SilencingPuromycin0
(0)

Shank 3 siRNA (m)

sc-42201mGene SilencingN/A0
(0)

Shank 3 shRNA Plasmid (m)

sc-42201-SHmGene SilencingPuromycin0
(0)

Shank 3 shRNA (m) Lentiviral Particles

sc-42201-VmGene SilencingPuromycin0
(0)

Shank 3 siRNA (r)

sc-270274rGene SilencingN/A
1
(0)

Shank 3 shRNA Plasmid (r)

sc-270274-SHrGene SilencingPuromycin
1
(0)

Shank 3 shRNA (r) Lentiviral Particles

sc-270274-VrGene SilencingPuromycin
1
(0)