Shank 3 Antibody (E-1): sc-377470

Shank 3 Antibody (E-1) is a mouse monoclonal IgG2a antibody that detects Shank 3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Shank 3 is a crucial component of the postsynaptic density, serving as a molecular scaffold that organizes and anchors glutamate receptors at excitatory synapses, which are essential for synaptic transmission and plasticity. Shank 3′s structure is characterized by multiple ankyrin repeat domains and PDZ domains, which facilitate interactions with various signaling molecules and receptors, thereby playing a pivotal role in synaptic signaling and stability. These structural features enable Shank 3 to recruit other proteins, such as betaPIX and PAK, to dendritic spines, influencing the morphology and function of synapses. Proper functioning of Shank 3 is vital for normal cognitive processes, and disruptions in expression or function have been implicated in neurodevelopmental disorders, highlighting Shank 3′s importance in maintaining synaptic integrity and communication in the brain. Anti-Shank 3 antibody (E-1) is an invaluable tool for researchers studying synaptic dynamics and related neurological conditions.

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Shank 3 Antibody (E-1) References:

1. Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders.  |  Durand, CM., et al. 2007. Nat Genet. 39: 25-7. PMID: 17173049
2. Dysfunction of cortical GABAergic neurons leads to sensory hyper-reactivity in a Shank3 mouse model of ASD.  |  Chen, Q., et al. 2020. Nat Neurosci. 23: 520-532. PMID: 32123378
3. Elevation of SHANK3 Levels by Antisense Oligonucleotides Directed Against the 3'-UTR of the Human SHANK3 mRNA.  |  Stirmlinger, N., et al. 2023. Nucleic Acid Ther. 33: 58-71. PMID: 36355061
4. SHANK3 in vagal sensory neurons regulates body temperature, systemic inflammation, and sepsis.  |  Zhang, L., et al. 2023. Front Immunol. 14: 1124356. PMID: 36845137
5. Thrombospondin1 mimics rapidly relieve depression via Shank3 dependent uncoupling between dopamine D1 and D2 receptors.  |  Gao, SQ., et al. 2023. iScience. 26: 106488. PMID: 37091229
6. YBX1-Mediated DNA Methylation-Dependent SHANK3 Expression in PBMCs and Developing Cortical Interneurons in Schizophrenia.  |  Ni, P., et al. 2023. Adv Sci (Weinh). 10: e2300455. PMID: 37211699
7. Evidence for common mechanisms of pathology between SHANK3 and other genes of Phelan-McDermid syndrome.  |  Mitz, AR., et al. 2024. Clin Genet. 105: 459-469. PMID: 38414139
8. Shank3 deficiency elicits autistic-like behaviors by activating p38α in hypothalamic AgRP neurons.  |  Wu, S., et al. 2024. Mol Autism. 15: 14. PMID: 38570876
9. Restoring thalamocortical circuit dysfunction by correcting HCN channelopathy in Shank3 mutant mice.  |  Guo, B., et al. 2024. Cell Rep Med. 5: 101534. PMID: 38670100
10. SHANK3 depletion leads to ERK signalling overdose and cell death in KRAS-mutant cancers.  |  Lilja, J., et al. 2024. Nat Commun. 15: 8002. PMID: 39266533

The preferred Shank 3 antibody is Shank 3 Antibody (C-4): sc-377088.