Shank 3 Activators
Shank 3 activators belong to a distinctive chemical class of compounds that have garnered significant attention in the field of neuroscience and neuropharmacology. These compounds are specifically designed to modulate the activity of the Shank 3 protein, which is a critical component of the post-synaptic density (PSD) in neurons. The Shank 3 protein, encoded by the SHANK3 gene, plays a pivotal role in the formation and maintenance of synapses, the junctions between nerve cells where communication occurs. Shank 3 activators are primarily designed to enhance the function of this protein within the synapse, with the ultimate goal of better understanding the molecular mechanisms underlying synaptic plasticity and the pathophysiology of certain neurodevelopmental and neuropsychiatric disorders.
Shank 3 activators typically exert their effects through various mechanisms, including the modulation of protein-protein interactions, phosphorylation, or the regulation of gene expression. By enhancing the activity of Shank 3, these compounds may have the potential to influence synaptic strength and stability, which are fundamental to processes such as learning, memory, and cognitive function. Understanding the function of Shank 3 and its modulators can provide invaluable insights into the intricate workings of the central nervous system and may shed light on the etiology of conditions like autism spectrum disorders, schizophrenia, and intellectual disabilities, which have been associated with disruptions in synaptic function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic acid is a short-chain fatty acid that has been shown to increase the expression of Shank3 through its histone deacetylase inhibitory activity, leading to changes in chromatin structure and enhanced gene transcription. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride influences various cellular pathways, including the Wnt signaling pathway, which has been implicated in the regulation of Shank3 expression. By modulating these pathways, lithium chloride can potentially upregulate the expression of Shank3. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, a metabolite of vitamin A, is involved in gene transcription regulation. It has been shown to influence the expression of various genes related to neural development and may have a role in inducing Shank3 expression through these mechanisms. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
17β-Estradiol, a form of estrogen, has been demonstrated to have neuroprotective effects and is involved in synaptic plasticity. It may upregulate Shank3 expression through its action on estrogen receptors, which are known to play a role in gene expression regulation in the brain. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin gallate, a catechin found in green tea, has various biological activities including anti-inflammatory and neuroprotective effects. It has been suggested to influence Shank3 expression, potentially through its action on cellular signaling pathways involved in neuronal development and function. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is a diterpene that activates adenylate cyclase, leading to an increase in cAMP levels within the cell. This increase in cAMP can lead to changes in gene expression, potentially including the upregulation of Shank3 expression. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone is a synthetic glucocorticoid that can influence gene expression through its action on glucocorticoid receptors. It has been shown to have effects on neuronal cells, and it may play a role in the regulation of Shank3 expression through its genomic actions. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is a polyphenolic compound found in turmeric with various biological activities. It has been shown to have neuroprotective effects and may influence Shank3 expression through its anti-inflammatory and antioxidant properties, as well as its ability to modulate cellular signaling pathways. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane is a compound found in cruciferous vegetables with well-known antioxidant and anti-inflammatory properties. It has been suggested to have neuroprotective effects, and its influence on Shank3 expression may be mediated through its action on cellular pathways involved in oxidative stress response and inflammation. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that can alter chromatin structure and influence gene expression. It has been shown to play a role in neuronal differentiation and may induce Shank3 expression through its effects on chromatin remodeling and transcriptional activation. | ||||||