SH3GL3 Inhibitors
SH3GL3 inhibitors are a class of chemical compounds specifically designed to target and inhibit the function of the SH3GL3 protein, also known as Endophilin B3. SH3GL3 is a member of the endophilin family of proteins characterized by the presence of an SH3 (Src Homology 3) domain and a BAR (Bin/Amphiphysin/Rvs) domain. This protein plays a significant role in the process of endocytosis, which is the cellular mechanism for internalizing molecules and membrane components from the extracellular environment. SH3GL3 is involved in the formation of vesicles and the regulation of membrane curvature, facilitating the trafficking of vesicles within the cell. It participates in various cellular processes such as receptor internalization, signal transduction, and the maintenance of synaptic vesicle pools in neurons.
Inhibitors of SH3GL3 function by binding to specific domains of the protein, such as the SH3 domain or the BAR domain, disrupting its normal interactions with lipids and other proteins. By interfering with these interactions, these inhibitors impede the protein's ability to facilitate vesicle formation and endocytic processes. This can lead to alterations in intracellular trafficking pathways and affect the distribution and function of cellular components. The development of SH3GL3 inhibitors involves detailed structural analysis of the protein to identify potential binding sites for inhibition. Techniques such as molecular docking, computational modeling, and biochemical assays are employed to design and optimize these compounds for high specificity and affinity. Studying SH3GL3 inhibitors provides valuable insights into the mechanisms of endocytosis and intracellular trafficking, enhancing our understanding of cellular function and the regulation of membrane dynamics.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein, through its tyrosine kinase inhibition, could impede the phosphorylation events required for the transcriptional activation of the SH3GL3 gene, potentially resulting in decreased SH3GL3 synthesis. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin may attenuate the expression of SH3GL3 by hindering kinase signaling pathways, leading to a reduction in the transcription factors necessary for SH3GL3 gene transcription. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol may downregulate SH3GL3 expression by obstructing the activation of specific transcription factors that bind to the SH3GL3 gene promoter, curtailing its transcriptional activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin could decrease SH3GL3 mRNA synthesis by suppressing nuclear factor-kappa B (NF-κB), which might be involved in the upregulation of the SH3GL3 gene under certain conditions. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin Gallate has the potential to decrease SH3GL3 expression by inhibiting the activity of certain transcription factors that stimulate the SH3GL3 gene, thus reducing its mRNA levels. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
DL-Sulforaphane may reduce SH3GL3 mRNA levels by activating the Nrf2 pathway, which could lead to a reprogramming of cellular defense mechanisms that include the downregulation of the SH3GL3 gene. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid may suppress SH3GL3 expression by binding to retinoic acid receptors that interact with the SH3GL3 promoter region, thereby repressing its transcription. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone could inhibit SH3GL3 expression by activating glucocorticoid receptors that interfere with transcription factor complexes involved in the initiation of SH3GL3 gene transcription. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A may lead to a decrease in SH3GL3 expression by inhibiting histone deacetylases, which results in a less condensed chromatin structure and suppression of transcription initiation at the SH3GL3 gene locus. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine may lead to the downregulation of SH3GL3 expression by causing hypomethylation of DNA, which could disrupt transcription factor binding to the SH3GL3 promoter. | ||||||