Sgs1 Inhibitors
Sgs1, a DNA helicase belonging to the RecQ family, plays a crucial role in maintaining genomic stability and integrity by participating in various DNA metabolic processes. Primarily, Sgs1 functions in DNA recombination, repair, and replication, where it unwinds DNA structures and resolves intermediates to ensure accurate DNA synthesis and repair. In recombination, Sgs1 promotes the dissolution of double Holliday junctions, preventing crossover events that could lead to genomic rearrangements. Additionally, Sgs1 is essential for the processing of stalled replication forks, preventing their collapse and facilitating DNA replication restart.
The inhibition of Sgs1 disrupts its vital roles in DNA metabolism, leading to profound consequences on genomic stability and cellular viability. Various chemicals act as direct inhibitors of Sgs1 by targeting different aspects of its function, including DNA unwinding, replication, and repair processes. These inhibitors interfere with Sgs1's ability to resolve DNA intermediates and promote accurate DNA synthesis and repair, ultimately leading to increased genomic instability and cellular dysfunction. Understanding the mechanisms of Sgs1 inhibition offers insights into the regulation of DNA metabolic processes and highlights potential strategies for modulating genomic stability in various biological contexts.
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $38.00 $58.00 $102.00 $202.00 | 8 | |
Geldanamycin inhibits Sgs1 through its interaction with Hsp90, a chaperone protein that stabilizes Sgs1. By disrupting the Hsp90-Sgs1 interaction, geldanamycin leads to the degradation of Sgs1, thereby inhibiting its function in DNA recombination and repair processes. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine inhibits Sgs1 by interfering with DNA repair processes. It disrupts the activation of ATM/ATR kinases, which are essential for phosphorylating Sgs1 and promoting its recruitment to DNA damage sites. This disruption leads to impaired DNA repair and increased genomic instability. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Camptothecin inhibits Sgs1 by trapping the enzyme in a covalent complex with DNA, preventing its unwinding activity during DNA replication and repair. This inhibition leads to the accumulation of DNA damage and the disruption of cellular processes dependent on Sgs1-mediated DNA unwinding. | ||||||
Novobiocin | 303-81-1 | sc-362034 sc-362034A | 5 mg 25 mg | $96.00 $355.00 | ||
Novobiocin inhibits Sgs1 by targeting bacterial gyrase, an enzyme homologous to eukaryotic topoisomerase II, which interacts with Sgs1 during DNA replication and repair. By inhibiting gyrase, novobiocin indirectly disrupts Sgs1 function, leading to impaired DNA processing and repair. | ||||||
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $82.00 $300.00 $1082.00 | 30 | |
Aphidicolin inhibits Sgs1 by blocking the activity of DNA polymerases, essential enzymes involved in DNA replication. By preventing DNA synthesis, aphidicolin indirectly impairs the function of Sgs1, which relies on DNA replication intermediates for its activity in DNA recombination and repair processes. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide inhibits Sgs1 by trapping the enzyme in a covalent complex with DNA, similar to camptothecin. This trapping prevents Sgs1 from unwinding DNA structures during replication and repair, leading to the accumulation of DNA damage and the disruption of cellular processes dependent on Sgs1-mediated DNA unwinding. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $65.00 $99.00 $140.00 | 85 | |
Mitomycin C inhibits Sgs1 by inducing DNA crosslinks, which interfere with DNA replication and repair processes. These crosslinks impede the progression of Sgs1 along DNA strands, leading to stalled replication forks and increased genomic instability. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D inhibits Sgs1 by intercalating into DNA strands, which disrupts the binding of Sgs1 to its substrate DNA. This interference prevents Sgs1 from unwinding DNA structures during replication and repair, leading to the accumulation of DNA damage and genomic instability. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Hydroxyurea inhibits Sgs1 by depleting cellular dNTP pools, which are essential for DNA replication. By reducing the availability of nucleotides, hydroxyurea indirectly impairs the function of Sgs1, which requires nucleotide substrates for its activity in DNA recombination and repair processes. | ||||||
Bleomycin | 11056-06-7 | sc-507293 | 5 mg | $270.00 | 5 | |
Bleomycin inhibits Sgs1 by inducing DNA strand breaks, which disrupt DNA replication and repair processes. These breaks interfere with the ability of Sgs1 to unwind DNA structures, leading to stalled replication forks and increased genomic instability. | ||||||