Molecular structure of Novobiocin, CAS Number: 303-81-1
Novobiocin (CAS 303-81-1)
Application:
Novobiocin is a potent inhibitor of bacterial DNA gyrase
CAS Number:
303-81-1
Purity:
≥95%
Molecular Weight:
612.60
Molecular Formula:
C31H36N2O11
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Novobiocin serves as a tool in the study of bacterial genetics and physiology due to its targeted mechanism of action against bacterial DNA gyrase, specifically the Topo II alpha subunit. By acting as a competitive inhibitor of the ATPase activity of the GyrB subunit, novobiocin effectively blocks the energy supply necessary for the supercoiling and unwinding processes essential to bacterial DNA replication and transcription. This inhibition provides researchers with a method to explore the dynamics of bacterial DNA manipulation under controlled experimental conditions, shedding light on the fundamental processes that govern bacterial survival and replication. Through its specific interaction with DNA gyrase, novobiocin is invaluable in dissecting the molecular underpinnings of bacterial resistance mechanisms and the development of other antibacterial agents.
Novobiocin (CAS 303-81-1) References
- Novobiocin: redesigning a DNA gyrase inhibitor for selective inhibition of hsp90. | Burlison, JA., et al. 2006. J Am Chem Soc. 128: 15529-36. PMID: 17132020
- Novobiocin and additional inhibitors of the Hsp90 C-terminal nucleotide-binding pocket. | Donnelly, A. and Blagg, BS. 2008. Curr Med Chem. 15: 2702-17. PMID: 18991631
- Topoisomerase II can relax; novobiocin is a mitochondrial poison after all. | Collins, A. 1990. Bioessays. 12: 493-4. PMID: 1964558
- Comparative efficacy of novobiocin and amoxicillin in experimental sepsis caused by beta-lactam-susceptible and highly resistant pneumococci. | Rodríguez-Cerrato, V., et al. 2010. Int J Antimicrob Agents. 35: 544-9. PMID: 20303716
- Novobiocin binding to NalD induces the expression of the MexAB-OprM pump in Pseudomonas aeruginosa. | Chen, W., et al. 2016. Mol Microbiol. 100: 749-58. PMID: 26844397
- Synthesis and Biological Evaluation of Novobiocin Core Analogues as Hsp90 Inhibitors. | Byrd, KM., et al. 2016. Chemistry. 22: 6921-31. PMID: 27037933
- The Antibiotic Novobiocin Binds and Activates the ATPase That Powers Lipopolysaccharide Transport. | May, JM., et al. 2017. J Am Chem Soc. 139: 17221-17224. PMID: 29135241
- Novobiocin Enhances Polymyxin Activity by Stimulating Lipopolysaccharide Transport. | Mandler, MD., et al. 2018. J Am Chem Soc. 140: 6749-6753. PMID: 29746111
- Homodimeric Tobramycin Adjuvant Repurposes Novobiocin as an Effective Antibacterial Agent against Gram-Negative Bacteria. | Idowu, T., et al. 2019. J Med Chem. 62: 9103-9115. PMID: 31557020
- Antimicrobial activities of amphiphilic cationic polymers and their efficacy of combination with novobiocin. | Miyagawa, A., et al. 2022. J Biomater Sci Polym Ed. 33: 299-312. PMID: 34559588
- Novobiocin antagonism of amastigotes of Trypanosoma cruzi growing in cell-free medium. | Pate, PG., et al. 1986. Antimicrob Agents Chemother. 29: 426-31. PMID: 3521485
- Novobiocin and rifampicin in combination against methicillin-resistant Staphylococcus aureus: an in-vitro comparison with vancomycin plus rifampicin. | Walsh, TJ., et al. 1986. J Antimicrob Chemother. 17: 75-82. PMID: 3633267
- Induction of resistance to novobiocin in the novobiocin-producing organism Streptomyces niveus. | Hoggarth, JH., et al. 1994. FEMS Microbiol Lett. 116: 131-6. PMID: 8150257
Inhibitor of:
AHSA2, ART2B, Bag-2, Cdc37, Cdc37L1, CRS4C-2, cryptdin 4, D630042P16Rik, DDX10, DDX19A, DDX19B, DDX35, DDX59, DinB, DNA pol 4, DnaJB12, DnaJC18, DnaJC25, E. coli, exonucleasefamily surface anchored protein, FKBP52, FLJ13236, GrpEL1, H2-M10.6, H2-M3, hCAP-D2, HEL308, HELIC1, HMGN3, HSP 105, HSP 75, HSP 78, HSP 90, HSPA2, HSPB9, HspBP1, HSPC196, L7RN6, Lex A, Lipocalin-5, LOC100040299, LOC100041119, LOC100041296, M13 filamentous phage, Mi2-β, MUP16, NSUN5C, OAT1, OAT3, P23, p91, PAI-RBP1, PDH-E1β, prefoldin 1, RecQL1, RRP36, RuvA, Sgs1, SGT1, SGTA, Shigatoxin 2, SLC22A11, SWAP, TCP-1 η, TCP-1 γ, TCP-1 θ, TCP-1 ζ, THAP9, Tns, Topo II alpha, Topo IIIβ, TPR, UBL5, UIP5, UNC45A, and Ydj1.Activator of:
1810011O10Rik, BC015286, Cyp60, DDX42, DnaJA2, FKBPL, HSP 90, HSP 90α, HSPC121, NYNRIN, prefoldin 3, STI1, TCP-1 δ, TCP-1 η, TCP-1 θ, TCP-1 ζ, and Trap1a.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Novobiocin, 5 mg | sc-362034 | 5 mg | $96.00 | |||
Novobiocin, 25 mg | sc-362034A | 25 mg | $355.00 |