Sgs1 Inhibitors

Sgs1, a DNA helicase belonging to the RecQ family, plays a crucial role in maintaining genomic stability and integrity by participating in various DNA metabolic processes. Primarily, Sgs1 functions in DNA recombination, repair, and replication, where it unwinds DNA structures and resolves intermediates to ensure accurate DNA synthesis and repair. In recombination, Sgs1 promotes the dissolution of double Holliday junctions, preventing crossover events that could lead to genomic rearrangements. Additionally, Sgs1 is essential for the processing of stalled replication forks, preventing their collapse and facilitating DNA replication restart.

The inhibition of Sgs1 disrupts its vital roles in DNA metabolism, leading to profound consequences on genomic stability and cellular viability. Various chemicals act as direct inhibitors of Sgs1 by targeting different aspects of its function, including DNA unwinding, replication, and repair processes. These inhibitors interfere with Sgs1's ability to resolve DNA intermediates and promote accurate DNA synthesis and repair, ultimately leading to increased genomic instability and cellular dysfunction. Understanding the mechanisms of Sgs1 inhibition offers insights into the regulation of DNA metabolic processes and highlights potential strategies for modulating genomic stability in various biological contexts.