Ser/Thr protein phosphatase (PP2C) Inhibitors
The PP2C family of serine/threonine protein phosphatases is a group of enzymes crucial for cellular signaling, playing a vital role in regulating various biological processes. These phosphatases are unique for their dependency on Mg²⁺ or Mn²⁺ ions for activity and are involved in pathways related to stress response, cell cycle regulation, and apoptosis. PP2C enzymes are known for their involvement in the regulation of the MAPK signaling pathways, particularly in deactivating the MAPKs, which are key players in cell proliferation and stress response. They also play a significant role in the regulation of the AMPK pathway, influencing cellular energy balance and metabolism. The PP2C family is characterized by a high degree of structural diversity, which allows them to participate in a wide range of cellular functions, often acting as key checkpoints in various signaling cascades.
Targeting the PP2C family of serine/threonine protein phosphatases for disruption or inhibition is a promising strategy for interventions where these enzymes play a pathogenic role. Inhibitors of PP2C can modulate the activity of various signaling pathways, potentially leading to the reactivation of stress responses or alteration of cell growth and metabolism.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
A broad-spectrum kinase inhibitor. By inhibiting multiple kinases that interact with the stress-activated protein kinase pathways, it can indirectly influence PP2C phosphatase activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
Inhibits p38 MAPK, which is a part of the stress-activated protein kinase pathways. Since PP2Cplays a role in these pathways, inhibiting p38 MAPK can indirectly modulate the activity of PP2Cζ. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
Inhibits JNK, another kinase within the stress-activated protein kinase pathways. By targeting JNK, it can indirectly affect PP2C functionality within this pathway. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
Inhibits MEK, a kinase upstream of the MAPK/ERK pathway. By influencing the MAPK/ERK pathway, PD98059 can indirectly modulate the downstream functions in which PP2Cmight be involved. | ||||||
Tenovin-6 | 1011557-82-6 | sc-224296 sc-224296A | 1 mg 5 mg | $272.00 $1214.00 | 9 | |
Impedes PP2C activity, potentially restoring p53 function and affecting cells. | ||||||
NSC348884 | 81624-55-7 | sc-301483 sc-301483A | 5 mg 25 mg | $125.00 $480.00 | 2 | |
Displays inhibitory effects on PP2C phosphatase activity, potentially impacting p53 signaling. | ||||||
Microperoxidase (MP-11) sodium salt | 104870-94-2 | sc-211907 sc-211907A | 5 mg 10 mg | $104.00 $209.00 | ||
Inhibits PP2C phosphatase activity, potentially affecting p53 function and cells. | ||||||
PP242 | 1092351-67-1 | sc-301606A sc-301606 | 1 mg 5 mg | $56.00 $169.00 | 8 | |
Inhibits mTORC1 and mTORC2, which have roles in signaling cascades interacting with stress-activated protein kinase pathways. This can indirectly affect PP2C functionality. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
Inhibits NF-κB activation. Given that NF-κB pathways can intersect with stress-activated protein kinase pathways, inhibiting NF-κB activation can have secondary effects on PP2C activity. | ||||||
Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 | 612847-09-3 | sc-202048 sc-202048A | 1 mg 5 mg | $204.00 $265.00 | 29 | |
Targets AKT, which is a part of the PI3K/AKT pathway. As this pathway can interact with stress-activated protein kinase pathways, inhibiting AKT can indirectly modulate PP2C role. | ||||||