Molecular structure of NSC348884, CAS Number: 81624-55-7
NSC348884 (CAS 81624-55-7)
See product citations (2)
Application:
NSC348884 is a biochemical which inhibitss NPM oligomer formation, upregulates p53 and induces apoptosis
CAS Number:
81624-55-7
Purity:
≥98%
Molecular Weight:
636.79
Molecular Formula:
C38H40N10
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
NSC348884 is a nucleolar phosphoprotein that displays several biological activities in ribosome biogenesis, cell proliferation, cytoplasmic/nuclear shuttle transportation, nucleic acid binding, ribonucleic cleavage, and centrosome duplication. NSC348884 is a putative inhibitor of nucleophosmin (nucleolar phosphoprotein B23). NSC348884 inhibits NPM oligomer formation, up-regulates p53 and induces apoptosis.
NSC348884 (CAS 81624-55-7) References
- NSC348884, a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis in human cancer cells. | Qi, W., et al. 2008. Oncogene. 27: 4210-20. PMID: 18345031
- Targeting levels or oligomerization of nucleophosmin 1 induces differentiation and loss of survival of human AML cells with mutant NPM1. | Balusu, R., et al. 2011. Blood. 118: 3096-106. PMID: 21719597
- [Inhibitory effect of NSC348884, a small molecular inhibitor of nucleophosmin, on the growth of hepatocellular carcinoma cell line hepG2]. | Zhang, J., et al. 2012. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 34: 58-61. PMID: 22737721
- Inhibition in vivo of the activity of botulinum neurotoxin A by small molecules selected by virtual screening. | Eichhorn, T., et al. 2012. Toxicon. 60: 1180-90. PMID: 22960451
- Interaction between nucleophosmin and HBV core protein increases HBV capsid assembly. | Jeong, H., et al. 2014. FEBS Lett. 588: 851-8. PMID: 24462683
- Nucleophosmin Regulates Intracellular Oxidative Stress Homeostasis via Antioxidant PRDX6. | Liu, GY., et al. 2017. J Cell Biochem. 118: 4697-4707. PMID: 28513872
- Nucleophosmin (NPM1)/B23 in the Proteome of Human Astrocytic Cells Restricts Chikungunya Virus Replication. | Abraham, R., et al. 2017. J Proteome Res. 16: 4144-4155. PMID: 28959884
- NPM1 as a potential therapeutic target for atypical teratoid/rhabdoid tumors. | Phi, JH., et al. 2019. BMC Cancer. 19: 848. PMID: 31462227
- Bmapaf-1 is Involved in the Response against BmNPV Infection by the Mitochondrial Apoptosis Pathway. | Wang, XY., et al. 2020. Insects. 11: PMID: 32971727
- Inhibition of nucleophosmin 1 suppresses colorectal cancer tumor growth of patient -derived xenografts via activation of p53 and inhibition of AKT. | Yu, ACY., et al. 2021. Cancer Biol Ther. 22: 112-123. PMID: 33446037
- NPM1 is a Novel Therapeutic Target and Prognostic Biomarker for Ewing Sarcoma. | Zhou, Y., et al. 2021. Front Genet. 12: 771253. PMID: 34899858
- Current status and future perspectives in targeted therapy of NPM1-mutated AML. | Ranieri, R., et al. 2022. Leukemia. 36: 2351-2367. PMID: 36008542
- Discovery of Novel PI3Kδ Inhibitors Based on the p110δ Crystal Structure. | Jia, W., et al. 2022. Molecules. 27: PMID: 36234743
- Exploratory study on the potential regulating role of Peroxiredoxin 6 on proteolysis and relationships with desmin early postmortem. | Wang, X., et al. 2023. Meat Sci. 195: 109021. PMID: 36335866
Inhibitor of:
B23, LIFR, LMO1, PITHD1, Ser/Thr protein phosphatase (PP2C), Wip1, and ZNF727.Activator of:
Nucleostemin.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NSC348884, 5 mg | sc-301483 | 5 mg | $125.00 | |||
NSC348884, 25 mg | sc-301483A | 25 mg | $480.00 |