Ser/Thr protein phosphatase (PP2C) Inhibidores

The PP2C family of serine/threonine protein phosphatases is a group of enzymes crucial for cellular signaling, playing a vital role in regulating various biological processes. These phosphatases are unique for their dependency on Mg²⁺ or Mn²⁺ ions for activity and are involved in pathways related to stress response, cell cycle regulation, and apoptosis. PP2C enzymes are known for their involvement in the regulation of the MAPK signaling pathways, particularly in deactivating the MAPKs, which are key players in cell proliferation and stress response. They also play a significant role in the regulation of the AMPK pathway, influencing cellular energy balance and metabolism. The PP2C family is characterized by a high degree of structural diversity, which allows them to participate in a wide range of cellular functions, often acting as key checkpoints in various signaling cascades.

Targeting the PP2C family of serine/threonine protein phosphatases for disruption or inhibition is a promising strategy for interventions where these enzymes play a pathogenic role. Inhibitors of PP2C can modulate the activity of various signaling pathways, potentially leading to the reactivation of stress responses or alteration of cell growth and metabolism.