SCYL1 Activators
SCYL1 can influence the protein's activity through a variety of mechanisms that modulate its phosphorylation state. Phosphatidylserine, a natural component of the cell membrane, can activate kinases when it translocates from the inner to the outer leaflet of the membrane. These kinases can phosphorylate SCYL1, leading to its activation. Forskolin, by directly stimulating adenylyl cyclase, raises intracellular cAMP levels, which in turn activates protein kinase A (PKA). PKA is known to phosphorylate a range of proteins, and SCYL1 could be among its targets. Similarly, dibutyryl-cAMP, a cAMP analog, can permeate cells and activate PKA, potentially resulting in the phosphorylation and activation of SCYL1. Ionomycin raises intracellular calcium levels, which can activate calmodulin and calcium/calmodulin-dependent protein kinases (CaMK), possibly leading to the phosphorylation of SCYL1.
Phorbol 12-myristate 13-acetate (PMA) mimics diacylglycerol and activates protein kinase C (PKC), which may target SCYL1 among its various substrates. Inhibitors like okadaic acid and Calyculin A impede the action of protein phosphatases PP1 and PP2A, which would typically dephosphorylate proteins, thereby maintaining SCYL1 in a phosphorylated and active state. Growth factors such as Epidermal Growth Factor (EGF) initiate a cascade of events upon binding to their receptors, leading to the activation of the MAPK/ERK pathway, which could phosphorylate SCYL1. Insulin engagement with its receptor sets off a signaling cascade that activates the PI3K/AKT pathway, and AKT may phosphorylate SCYL1. Hydrogen peroxide serves as a signaling molecule that can activate kinases capable of SCYL1 phosphorylation. Anisomycin, while inhibiting protein synthesis, also activates the JNK pathway, which could lead to SCYL1 phosphorylation. Spermine, through its modulation of ion channels and kinases, may alter SCYL1 phosphorylation. Each of these chemicals, through their unique interactions with cellular pathways, contributes to the regulation of SCYL1's activation state.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L-α-Lecithin, Egg Yolk, Highly Purified | 8002-43-5 | sc-203096 | 250 mg | $135.00 | ||
Phosphatidylserine is a phospholipid component typically found on the inner leaflet of the plasma membrane, which can play a role in activating kinases that are involved in the signaling pathways where SCYL1 is implicated. The externalization of phosphatidylserine to the outer leaflet can serve as a signal for macrophage recognition, but internally it may activate kinases that phosphorylate SCYL1, leading to its functional activation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentration. Calcium ions can activate calmodulin and calcium/calmodulin-dependent protein kinases (CaMK), which may phosphorylate SCYL1 and thus enhance its functional activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a diacylglycerol (DAG) analog which activates protein kinase C (PKC). PKC is known to phosphorylate a wide array of proteins, and although not directly linked to SCYL1, it could potentially phosphorylate and activate SCYL1 as part of its broad spectrum of substrates. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases PP1 and PP2A. Inhibition of these phosphatases can result in increased phosphorylation levels of cellular proteins, including potentially SCYL1, thereby maintaining or enhancing its activity due to reduced dephosphorylation. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Similar to okadaic acid, Calyculin A is also an inhibitor of protein phosphatases, particularly PP1 and PP2A. By inhibiting these phosphatases, Calyculin A could increase the phosphorylation state and thus the activity of SCYL1. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin binds to its receptor, triggering a signaling cascade that activates PI3K/AKT pathway. AKT can phosphorylate multiple downstream targets, which might include SCYL1, leading to its activation. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
Hydrogen peroxide is a reactive oxygen species that can act as a signaling molecule, leading to the activation of various kinases through oxidative mechanisms, which may include kinases that phosphorylate and activate SCYL1. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl-cAMP is a cell-permeable cAMP analog that activates cAMP-dependent PKA. PKA can phosphorylate various proteins in the cell, potentially including SCYL1, resulting in its activation. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that can also activate stress-activated protein kinases (SAPKs) such as JNK. Activation of these kinases can lead to phosphorylation of target proteins, possibly including SCYL1, thus leading to its activation. | ||||||
Spermine | 71-44-3 | sc-212953A sc-212953 sc-212953B sc-212953C | 1 g 5 g 25 g 100 g | $61.00 $196.00 $277.00 $901.00 | 1 | |
Spermine is a polyamine that can modulate various ion channels and may affect kinase activity. Through these interactions, spermine might alter the phosphorylation status of proteins like SCYL1, potentially leading to its activation. | ||||||