SCYL1 Inhibitors
SCYL1 inhibitors encompass a range of compounds that indirectly affect the functional activity of SCYL1 by targeting various cellular processes and pathways integral to its function. Compounds such as Brefeldin A and Golgicide A specifically target the Golgi apparatus, a cellular organelle associated with SCYL1's role in protein trafficking. Brefeldin A disrupts the structure and function of the Golgi by inhibiting Golgi-associated ARF proteins, thus potentially impeding SCYL1's activity in vesicle formation and maintenance of Golgi integrity. Similarly, Golgicide A's inhibition of GBF1, a factor essential for Golgi function, may affect SCYL1 by altering the Golgi dynamics crucial for its function.
Other compounds like Nocodazole and Paclitaxel target microtubule dynamics, which are fundamental for intracellular transport and the proper localization of proteins like SCYL1. Nocodazole disrupts microtubule polymerization, which can lead to a breakdown in the trafficking routes that SCYL1 is involved in, while Paclitaxel stabilizes microtubules to an extent that might prevent the normal dynamic rearrangement required for SCYL1's trafficking functions. The effects of these compounds on the microtubule network demonstrate how alterations in cellular infrastructure can indirectly inhibit SCYL1 activity by impeding its role in cellular trafficking.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
A fungal metabolite that disrupts the structure and function of the Golgi apparatus by inhibiting ADP-ribosylation factor (ARF), which is necessary for vesicle formation from the Golgi. This disruption can inhibit SCYL1 by affecting its Golgi-associated functions. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $152.00 $515.00 | ||
An ionophore that alters intracellular ion gradients, especially sodium and hydrogen ions, affecting the Golgi apparatus's pH and ion balance. This alteration can inhibit SCYL1 indirectly by impairing the Golgi's environment where SCYL1 operates. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
A microtubule-disrupting agent that interferes with microtubule polymerization, impacting intracellular transport and the proper functioning of the Golgi apparatus, indirectly affecting SCYL1 by disrupting its trafficking role. | ||||||
Golgicide A | 1005036-73-6 | sc-215103 sc-215103A | 5 mg 25 mg | $187.00 $670.00 | 11 | |
A specific inhibitor of the Golgi brefeldin A resistance factor 1 (GBF1), a GEF for ARF, which plays a crucial role in maintaining Golgi structure and function, thereby indirectly inhibiting SCYL1 by altering Golgi dynamics. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
A GSK-3 inhibitor that can influence Wnt signaling pathway, potentially altering cellular processes and protein trafficking that SCYL1 is associated with, thereby indirectly affecting its function. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
An N-glycosylation inhibitor that disrupts protein folding within the ER, leading to ER stress and potentially impacting Golgi function, indirectly affecting SCYL1's role in protein trafficking. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
A SERCA pump inhibitor that induces ER stress by depleting ER calcium stores, which could disrupt the ER-Golgi trafficking axis and indirectly inhibit SCYL1 function. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $87.00 | 44 | |
A small molecule that inhibits dynamin, impacting clathrin-mediated endocytosis and potentially affecting the trafficking routes SCYL1 is involved in. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
A tyrosine kinase inhibitor that can modulate various signaling pathways and potentially affect the intracellular trafficking system where SCYL1 functions. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
An actin polymerization inhibitor that disrupts cytoskeleton dynamics, which can indirectly affect SCYL1 by altering the cell's trafficking machinery it is involved with. | ||||||