Molecular structure of Golgicide A, CAS Number: 1005036-73-6
Golgicide A (CAS 1005036-73-6)
See product citations (11)
Alternate Names:
6,8-Difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline
Application:
Golgicide A is a potent, highly specific, reversible inhibitor of the cis-Golgi ArfGEF GBF1
CAS Number:
1005036-73-6
Purity:
≥98%
Molecular Weight:
284.30
Molecular Formula:
C17H14F2N2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Golgicide A, a potent and selective inhibitor of the Golgi BFA resistance factor 1 (GBF1), stands out in cell biology and biochemical research for its unique mechanism of action, targeting the secretory pathway. By specifically inhibiting GBF1, Golgicide A disrupts the Arf1-mediated recruitment of coat proteins to Golgi membranes, which is essential for vesicle formation and trafficking. This disruption leads to a blockage in the transport of proteins and lipids through the Golgi apparatus, providing a powerful tool for dissecting the intricacies of intracellular trafficking and Golgi apparatus function. The ability of Golgicide A to selectively target this critical node in the secretory pathway allows researchers to explore the fundamental aspects of cell biology, including the role of the Golgi apparatus in protein modification, sorting, and the maintenance of cellular homeostasis. Furthermore, its application extends to the study of diseases where alterations in Golgi function and protein trafficking are implicated, offering a valuable approach to understand pathological mechanisms at a molecular level.
Golgicide A (CAS 1005036-73-6) References
- Golgicide A reveals essential roles for GBF1 in Golgi assembly and function. | Sáenz, JB., et al. 2009. Nat Chem Biol. 5: 157-65. PMID: 19182783
- Differential effects of the putative GBF1 inhibitors Golgicide A and AG1478 on enterovirus replication. | van der Linden, L., et al. 2010. J Virol. 84: 7535-42. PMID: 20504936
- COPI is required for enterovirus 71 replication. | Wang, J., et al. 2012. PLoS One. 7: e38035. PMID: 22662263
- Distinct biological effects of golgicide a derivatives on larval and adult mosquitoes. | Mack, DJ., et al. 2012. Bioorg Med Chem Lett. 22: 5177-81. PMID: 22818079
- Small molecules intercept Notch signaling and the early secretory pathway. | Krämer, A., et al. 2013. Nat Chem Biol. 9: 731-8. PMID: 24077179
- CSFV proliferation is associated with GBF1 and Rab2. | Liang, W., et al. 2017. J Biosci. 42: 43-56. PMID: 28229964
- Cell survival and protein secretion associated with Golgi integrity in response to Golgi stress-inducing agents. | Ignashkova, TI., et al. 2017. Traffic. 18: 530-544. PMID: 28485883
- Image-based drug screen identifies HDAC inhibitors as novel Golgi disruptors synergizing with JQ1. | Gendarme, M., et al. 2017. Mol Biol Cell. 28: 3756-3772. PMID: 29074567
- Identification of GBF1 as a cellular factor required for hepatitis E virus RNA replication. | Farhat, R., et al. 2018. Cell Microbiol. 20: PMID: 29112323
- Golgi stress mediates redox imbalance and ferroptosis in human cells. | Alborzinia, H., et al. 2018. Commun Biol. 1: 210. PMID: 30511023
- Herpes Simplex Virus Entry by a Nonconventional Endocytic Pathway. | Tebaldi, G., et al. 2020. J Virol. 94: PMID: 33028710
- ARF1 with Sec7 Domain-Dependent GBF1 Activates Coatomer Protein I To Support Classical Swine Fever Virus Entry. | Zhang, L., et al. 2022. J Virol. 96: e0219321. PMID: 35044210
- 2,4-Diacetylphloroglucinol Reduces Beta-Amyloid Production and Secretion by Regulating ADAM10 and Intracellular Trafficking in Cellular and Animal Models of Alzheimer's Disease. | Jang, BG., et al. 2022. Cells. 11: PMID: 36010661
- Kinetics of Arf1 inactivation regulates Golgi organisation and function in non-adherent fibroblasts. | B R, R., et al. 2023. Biol Open. 12: PMID: 36946871
Inhibitor of:
β′-COP, γ-SNAP, ζ2-COP, 2410002O22Rik, ACBD3, ADP-ribosylation factor (ARF), AGAP1, AP-1μ2, AP-3σ2, AP1GBP1, AP3 Adaptor Complex, ARF1, Arf2, ARF7, ARFGAP, ARFGAP2, ARFGAP3, ARFGEF (BIG1, BIG2, BIG3), ARFRP1, ARL4, ARL5C, BET3L, BET5, C11orf2, C4orf16, CASC4, CCDC115, CCPG1, COG1, COG3, COG4, COG5, COG6, COG8, Component of oligomeric golgi complex (COG), COPD, copGFP, COPI (Coat Protein Complex I), COPZ2, CTAGE6, cytohesin-2, D030016E14Rik, DENND4C, Dopey-1, EG433102, Epsilon-COP, ERGIC-53L, Exocyst complex component (EXOC), FAM18A, GBF1, GGA3, Giantin, GM130, Gm581, Gm949, GOLGA6A, GOLGA6A-D, GOLGA6B, GOLGA6C, GOLGA6D, GOLGA6L, GOLGA6L1, GOLGA6L10, GOLGA6L4, GOLGA6L9, GOLGA7B, GOLGA8A, GOLGA8G, GOLGA8J, GOLGA8K, GOLGA8O, GOLGA8R, GOLGB1, golgin 160, golgin 245, Golgin 45, golgin 84, golgin 97, GOLT1A, GRASP55, GRASP65, Jaw1, LOC645202, LOC727909, Lunapark, MIA2, MON1A, MS4A6C, NSF, PACS-1b, POR1, Rab 35, Rab 3C, Rab 6, Rab 6A, Rab11-FIP4, REEP3, RINT-1, RSC1A1, Sar1, Sar1a, SCFD2, SCYL1, Sec1, Sec15B, SEC16A, SEC16L, SEC16S, SEC22A, SEC22B, SEC22C, SEC24A, Sec24C, Sec31A, SFT2D1, SFT2D3, Sso1, Sso2, Syntaxin 12, tepsin, TGN38, TI-VAMP, TIP20, TMED1, TMED2, TMED4, TMED7, TMED8, TMED9, TMEM192, TMP21, TMTC1, TRAPPC2L, TRAPPC6B, UHRF1BP1, USO1 (vesicle transport factor; p115), v-SNARE Vti1a, VEPH1, VPS51, WDR11, YIF1A, YIPF1, YIPF3, YIPF4, YIPF5, YIPF7, and YJEFN3.Activator of:
ARL7, Bet1L, COPG, D030016E14Rik, D030074E01Rik, DENND1B, DKFZp761E198, EG433102, ERGIC-3, FLJ13611, GAAP, GCC2, GnT-I, GOLGA6A, GOLGA6L4, GOLGA8H, GOLGA8J, GOLPH3, GOLT1B, MS4A6C, Rab 1A, Rab 2A, Rab 43, Rab 5C, RAM, Sec31, SYS1, TMCC1, TMEM191B, TMEM191C, TMEM207, TMEM211, TMEM64, TMEM74, TRS85, YIPF2, and YIPF6.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Golgicide A, 5 mg | sc-215103 | 5 mg | $187.00 | |||
Golgicide A, 25 mg | sc-215103A | 25 mg | $670.00 |