scotin Inhibitors
Chemical inhibitors of Scotin can exert their inhibitory effects through various mechanisms that induce endoplasmic reticulum (ER) stress, leading to altered Scotin activity. Brefeldin A disrupts vesicle transport by inhibiting ADP-ribosylation factor, causing ER stress and engaging Scotin in apoptosis rather than its normal regulatory roles. Similarly, Thapsigargin and Cyclopiazonic Acid inhibit the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), depleting ER calcium stores and inducing ER stress, which can shift Scotin's activity from its typical functions to handling stress-induced misfolded proteins. Tunicamycin blocks N-linked glycosylation, a necessary process for proper protein folding, which can cause the accumulation of misfolded proteins in the ER and thus impair Scotin's usual functions as it becomes involved in abnormal protein response activities.
Furthermore, Salubrinal and Guanabenz, through the selective inhibition of eIF2α dephosphorylation, increase the unfolded protein response, potentially inhibiting Scotin by fixating its function on managing misfolded proteins. MG-132, as a proteasome inhibitor, causes the accumulation of polyubiquitinated proteins, leading to ER stress which can divert Scotin's function towards proteostasis maintenance. Eeyarestatin I directly inhibits ER-associated degradation (ERAD), accumulating misfolded proteins within the ER and thus inhibiting Scotin by engaging it in ER stress responses. The action of 2-Deoxy-D-glucose, which inhibits glycolysis, can also lead to ER stress through energy depletion, engaging Scotin in stress responses. Azoramide, by enhancing the folding capacity of the ER, can reduce Scotin's involvement in the unfolded protein response, thereby inhibiting its regular activity. ISRIB, by reversing the effects of eIF2α phosphorylation, and GSK2606414, through PERK inhibition, can prevent the engagement of Scotin in the ER stress response, thereby maintaining its regular cellular functions but at a decreased activity level due to the absence of stress signaling that Scotin would normally respond to.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A is an inhibitor of ADP-ribosylation factor (ARF), a GTPase involved in vesicle transport between the Golgi and the endoplasmic reticulum. Scotin is known to reside in the endoplasmic reticulum and is involved in ER stress-induced apoptosis. By disrupting the function of ARF, Brefeldin A can lead to ER stress, which in turn could enhance the activity of Scotin in promoting apoptosis, functionally inhibiting its normal regulatory roles within the ER. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a sesquiterpene lactone that inhibits the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to an increase in cytosolic calcium levels. Elevated cytosolic calcium induces ER stress and can activate the unfolded protein response, in which Scotin is implicated. This stress can disrupt normal Scotin function by pushing the protein to participate in stress response rather than its regular cellular roles. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Tunicamycin inhibits N-linked glycosylation in the ER, which is essential for proper protein folding and function. As Scotin is involved in ER stress pathways, tunicamycin-induced ER stress could impair Scotin's typical function by engaging it in abnormal protein response activities. | ||||||
Cyclopiazonic Acid | 18172-33-3 | sc-201510 sc-201510A | 10 mg 50 mg | $176.00 $624.00 | 3 | |
Cyclopiazonic Acid is an inhibitor of SERCA, leading to depletion of ER calcium stores. Similar to thapsigargin, this depletion can cause ER stress, potentially impairing Scotin's ability to carry out its regular functions by engaging it in the unfolded protein response. | ||||||
Salubrinal | 405060-95-9 | sc-202332 sc-202332A | 1 mg 5 mg | $34.00 $104.00 | 87 | |
Salubrinal selectively blocks the dephosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2α), which plays a critical role in protein synthesis and ER stress response. By blocking normal eIF2α function, Salubrinal can enhance ER stress, potentially inhibiting Scotin by fixating its function on handling misfolded proteins. | ||||||
Guanabenz acetate | 23256-50-0 | sc-203590 sc-203590A sc-203590B sc-203590C sc-203590D | 100 mg 500 mg 1 g 10 g 25 g | $102.00 $468.00 $832.00 $4162.00 $7283.00 | 2 | |
Guanabenz acetate selectively inhibits the dephosphorylation of eIF2α, similar to Salubrinal. This can lead to ER stress and an unfolded protein response, thereby potentially inhibiting Scotin by shifting its activity towards this stress response. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG-132 is a proteasome inhibitor that can lead to the accumulation of polyubiquitinated proteins, causing ER stress. As Scotin is implicated in the ER stress response, the MG-132-induced stress could inhibit Scotin's regular functions by engaging it in proteostasis maintenance. | ||||||
Eeyarestatin I | 412960-54-4 | sc-358130B sc-358130 sc-358130A sc-358130C sc-358130D sc-358130E | 5 mg 10 mg 25 mg 50 mg 100 mg 500 mg | $114.00 $203.00 $354.00 $697.00 $1363.00 $5836.00 | 12 | |
Eeyarestatin I inhibits the ER-associated degradation (ERAD) pathway. This inhibition can result in ER stress, which is known to involve Scotin, potentially inhibiting its regular functions due to the accumulation of misfolded proteins in the ER. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
2-Deoxy-D-glucose inhibits glycolysis and can mimic glucose deprivation, leading to ER stress as a result of energy depletion. This could inhibit Scotin by engaging it in cellular stress responses rather than performing its normal regulatory duties. | ||||||
ISRIB | 1597403-47-8 | sc-488404 | 10 mg | $300.00 | 1 | |
ISRIB reverses the effects of eIF2α phosphorylation, counteracting the integrated stress response. By normalizing protein synthesis rates, ISRIB could inhibit Scotin functionally by preventing it from responding to ER stress-related misfolded proteins. | ||||||