scotin Antibody (C-7): sc-390725
- scotin Antibody (C-7) is a mouse monoclonal IgG1 κ scotin antibody, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 151-192 mapping near the C-terminus of scotin of human origin
- scotin Antibody (C-7) is recommended for detection of scotin of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-scotin Antibody (C-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for scotin Antibody (C-7) for WB applications. These reagents are now offered in bundles with scotin Antibody (C-7) (see ordering information below).
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SEE ALSO...
Scotin Antibody (C-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects scotin protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-scotin antibody (C-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Scotin, also known as Protein shisha-5 or Putative NFκB-activating protein 120, is a 240 amino acid single-pass type I membrane protein that primarily localizes to the endoplasmic reticulum and nucleus, playing a crucial role in cellular signaling pathways. Scotin′s localization is significant as scotin is involved in the regulation of apoptosis, with both caspase-dependent and p53/TP53-dependent pathways being influenced by scotin′s activity. Scotin protein is particularly abundant in murine spleen and thymus tissues, highlighting scotin′s potential role in immune responses. The gene encoding scotin is located on human chromosome 3, a region that harbors over 1,100 genes, including several key tumor suppressor genes and those associated with various genetic disorders such as Marfan Syndrome and von Hippel-Lindau syndrome. Scotin′s presence in these critical cellular processes underscores scotin′s importance in maintaining cellular homeostasis and potential implications in cancer biology and therapeutic interventions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
scotin Antibody (C-7) References:
- Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane. | Bourdon, JC., et al. 2002. J Cell Biol. 158: 235-46. PMID: 12135983
- The DNA sequence, annotation and analysis of human chromosome 3. | Muzny, DM., et al. 2006. Nature. 440: 1194-8. PMID: 16641997
- The calcium binding protein ALG-2 binds and stabilizes Scotin, a p53-inducible gene product localized at the endoplasmic reticulum membrane. | Draeby, I., et al. 2007. Arch Biochem Biophys. 467: 87-94. PMID: 17889823
- Scotin: A new p63 target gene expressed during epidermal differentiation. | Zocchi, L., et al. 2008. Biochem Biophys Res Commun. 367: 271-6. PMID: 18164684
- Cell cycle regulation by the pro-apoptotic gene Scotin. | Gupta, RK., et al. 2008. Cell Cycle. 7: 2401-8. PMID: 18677103
- Alterations of 3p21.31 tumor suppressor genes in head and neck squamous cell carcinoma: Correlation with progression and prognosis. | Ghosh, S., et al. 2008. Int J Cancer. 123: 2594-604. PMID: 18792900
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
scotin Antibody (C-7) | sc-390725 | 200 µg/ml | $322.00 | |||
scotin Antibody (C-7): m-IgG Fc BP-HRP Bundle | sc-530243 | 200 µg Ab; 10 µg BP | $361.00 | |||
scotin Antibody (C-7): m-IgGκ BP-HRP Bundle | sc-523655 | 200 µg Ab, 40 µg BP | $361.00 | |||
scotin Antibody (C-7): m-IgG1 BP-HRP Bundle | sc-543952 | 200 µg Ab; 20 µg BP | $361.00 | |||
scotin Antibody (C-7) AC | sc-390725 AC | 500 µg/ml, 25% agarose | $424.00 | |||
scotin Antibody (C-7) HRP | sc-390725 HRP | 200 µg/ml | $322.00 | |||
scotin Antibody (C-7) FITC | sc-390725 FITC | 200 µg/ml | $336.00 | |||
scotin Antibody (C-7) PE | sc-390725 PE | 200 µg/ml | $349.00 | |||
scotin Antibody (C-7) Alexa Fluor® 488 | sc-390725 AF488 | 200 µg/ml | $364.00 | |||
scotin Antibody (C-7) Alexa Fluor® 546 | sc-390725 AF546 | 200 µg/ml | $364.00 | |||
scotin Antibody (C-7) Alexa Fluor® 594 | sc-390725 AF594 | 200 µg/ml | $364.00 | |||
scotin Antibody (C-7) Alexa Fluor® 647 | sc-390725 AF647 | 200 µg/ml | $364.00 | |||
scotin Antibody (C-7) Alexa Fluor® 680 | sc-390725 AF680 | 200 µg/ml | $364.00 | |||
scotin Antibody (C-7) Alexa Fluor® 790 | sc-390725 AF790 | 200 µg/ml | $364.00 |