The class of chemical compounds known as scc-112_Pds5a inhibitors is a specialized group of molecules designed to interact with and modulate the activity of the scc-112 protein complex, which includes Pds5a as one of its essential components. Scc-112 is a crucial player in various cellular processes, particularly in the context of chromosome organization, condensation, and segregation during cell division. Pds5a, as a component of this complex, is involved in mediating the cohesion and proper alignment of sister chromatids, ensuring the accurate distribution of genetic material to daughter cells. Inhibitors targeting scc-112_Pds5a aim to either disrupt the formation or function of this protein complex or modulate its activity, thus influencing chromosomal dynamics and cell division processes.
The development and study of scc-112_Pds5a inhibitors are rooted in the fundamental understanding of cell cycle regulation and genomic stability. Proper chromosome segregation is essential for the maintenance of genetic integrity, and any dysregulation in this process can lead to various cellular abnormalities, including aneuploidy and genomic instability. These inhibitors offer a means to probe the intricate molecular mechanisms involved in chromosome cohesion and segregation, allowing researchers to gain insights into cell cycle regulation and the maintenance of genomic fidelity. Investigations into scc-112_Pds5a inhibitors may provide valuable contributions to the broader field of cell biology, shedding light on the molecular underpinnings of chromosome dynamics, which are crucial for normal cellular function and development.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This cytidine analog can incorporate into DNA and impact gene expression, potentially affecting PDS5A expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
As a histone deacetylase inhibitor, it can influence chromatin structure and might indirectly affect cohesin function. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Another histone deacetylase inhibitor that can alter chromatin structure and subsequently cohesin's chromatin association. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $210.00 $305.00 $495.00 | 10 | |
PARP inhibitor that affects DNA repair pathways. Given cohesin's role in DNA repair, this could influence cohesin-associated proteins like PDS5A. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
DNA cross-linking agent that can disturb DNA structure and potentially influence cohesin-associated functions. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Inhibits DNA topoisomerase I, potentially affecting DNA structure and indirectly impacting cohesin functions. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Inhibits DNA topoisomerase II, which might influence chromatin structure and cohesin's chromatin association. | ||||||
L-Mimosine | 500-44-7 | sc-201536A sc-201536B sc-201536 sc-201536C | 25 mg 100 mg 500 mg 1 g | $36.00 $88.00 $220.00 $436.00 | 8 | |
Inhibits DNA synthesis, potentially affecting chromosome structure and cohesin-associated processes. | ||||||
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $84.00 $306.00 $1104.00 | 30 | |
DNA polymerase inhibitor which might disturb DNA synthesis and indirectly influence cohesin's functions. | ||||||
Daunorubicin hydrochloride | 23541-50-6 | sc-200921 sc-200921A sc-200921B sc-200921C | 10 mg 50 mg 250 mg 1 g | $105.00 $438.00 $837.00 $1569.00 | 4 | |
Intercalates into DNA, potentially affecting chromatin structure and cohesin's role in chromosomal processes. | ||||||