S-100Z Activators
S-100Z activators are a diverse group of compounds that enhance the protein's activity through various biochemical mechanisms. Some activators work by increasing the levels of intracellular second messengers, such as cAMP, which in turn activate protein kinases that phosphorylate transcription factors, leading to upregulation of S-100Z activity. Others exert their influence by binding to specific receptors that increase intracellular calcium levels, a critical cofactor for S-100Z, thus promoting its activation. These activators may function via different receptors or channels, but ultimately they converge on the common endpoint of elevating calcium within the cell, which is essential for the function of this calcium-binding protein. This elevation in calcium can activate numerous downstream signaling pathways, culminating in the potentiation of S-100Z's biological activities.
In addition to second messenger modulation, certain activators directly influence protein kinases that play a role in calcium-dependent signaling pathways. For example, direct activation of protein kinase C can lead to the phosphorylation of target proteins that interact with or regulate S-100Z activity. Another set of activators disrupts calcium homeostasis by inhibiting calcium pumps within intracellular stores, causing a sustained increase in cytosolic calcium that can further stimulate S-100Z function.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Activates adenylate cyclase, increasing cAMP levels, which in turn activates PKA. PKA phosphorylates transcription factors that enhance the transcription and activity of S-100Z. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
A synthetic catecholamine that activates beta-adrenergic receptors, leading to adenylate cyclase activation, cAMP accumulation, and PKA activation, thus promoting the phosphoregulation and increased activity of S-100Z. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Directly activates protein kinase C (PKC), which can phosphorylate target proteins and could enhance the activity of S-100Z by modulating calcium-dependent signaling pathways with which S-100Z is associated. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
A calcium ionophore that raises intracellular calcium levels, potentially activating calcium-dependent proteins and signaling pathways, thereby increasing the activity of S-100Z, which binds calcium. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A calcium ionophore that elevates intracellular calcium concentration, possibly stimulating calcium-sensitive signaling mechanisms that upregulate S-100Z activity. | ||||||
Nicotinic Acid | 59-67-6 | sc-205768 sc-205768A | 250 g 500 g | $61.00 $122.00 | 1 | |
Binds to G protein-coupled receptors, leading to increased intracellular calcium levels and activation of downstream signaling pathways, which may indirectly increase the activity of S-100Z. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $82.00 $192.00 $801.00 | ||
L-type calcium channel agonist that increases calcium influx, potentially activating downstream calcium-dependent proteins and signaling cascades, thereby potentially enhancing the activity of S-100Z. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Activates the stress-activated protein kinase (SAPK) pathway, which could lead to the induction of signaling cascades that enhance the activity of S-100Z. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
A cAMP analog that activates PKA, thus possibly leading to enhanced phosphorylation of proteins and transcription factors that increase S-100Z activity. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $92.00 $277.00 $969.00 | 7 | |
Binds to histamine receptors which can increase intracellular calcium levels and activate calcium-dependent signaling pathways, potentially leading to increased activity of S-100Z. | ||||||