RPUSD2 Inhibitors
RPUSD2 inhibitors pertain to a class of chemical agents that are specifically designed to interact with and inhibit the activity of the RNA pseudouridylate synthase domain-containing protein 2 (RPUSD2). RPUSD2 is an enzyme that plays a pivotal role in the modification of RNA molecules, a process that is essential for the proper functioning of cellular machinery. The modification in question involves the conversion of uridine residues in RNA to pseudouridine, which is a critical step in the post-transcriptional modification of transfer RNA (tRNA) and other small nuclear RNAs (snRNAs). Pseudouridylation can impact the stability, structure, and function of RNA molecules, thereby influencing the intricate network of RNA-protein interactions within the cell. Inhibitors that target RPUSD2 are designed to bind to this enzyme, effectively blocking its activity and consequently altering the pseudouridylation landscape within the cellular environment.
The development and function of RPUSD2 inhibitors require an understanding of the intricate biochemistry governing RNA processing. These inhibitors are often the product of extensive medicinal chemistry efforts that aim to create molecules with high affinity and specificity for RPUSD2. The specificity is crucial, as it ensures that the inhibitor exerts its effect on the intended target without inadvertently disrupting other enzymes or processes. This is achieved through the careful design of the inhibitor's structure, which is informed by the three-dimensional conformation of the RPUSD2 active site. The interaction between RPUSD2 inhibitors and the enzyme is typically characterized by various bonding interactions, including hydrogen bonds, hydrophobic interactions, and sometimes ionic bonds, which together contribute to the potency and selectivity of these inhibitors. The study of RPUSD2 inhibitors involves a multidisciplinary approach, incorporating biochemistry, molecular biology, and structural biology to elucidate the mechanism by which these compounds exert their effects at the molecular level.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Omeprazole | 73590-58-6 | sc-202265 | 50 mg | $66.00 | 4 | |
Omeprazole, a proton pump inhibitor, indirectly inhibits RPUSD2 by reducing cellular acidity, which may affect the mitochondrial matrix pH and therefore the proper function of mitochondrial proteins, including RPUSD2, which is involved in mitochondrial RNA modification. | ||||||
Chloramphenicol | 56-75-7 | sc-3594 | 25 g | $53.00 | 10 | |
Chloramphenicol acts by inhibiting bacterial protein synthesis. It can also inhibit mitochondrial protein synthesis in eukaryotic cells, thereby potentially reducing the activity of RPUSD2 by limiting its expression, as RPUSD2 is a mitochondrial protein. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $173.00 $418.00 | 43 | |
Doxorubicin intercalates into DNA and disrupts topoisomerase-II-mediated DNA repair. This drug may indirectly affect RPUSD2 by causing mitochondrial DNA damage and dysfunction, which can compromise the proteins associated with mitochondrial RNA processing, including RPUSD2. | ||||||
Actinonin | 13434-13-4 | sc-201289 sc-201289B | 5 mg 10 mg | $160.00 $319.00 | 3 | |
Actinonin is a peptide antibiotic that inhibits bacterial and mitochondrial peptide deformylase, potentially decreasing the synthesis of mitochondrial proteins and indirectly affecting the function of mitochondrial RNA-modifying proteins such as RPUSD2. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $254.00 | 41 | |
Rotenone is an inhibitor of mitochondrial complex I. By disrupting normal electron transport and ATP synthesis, it may indirectly reduce the activity of RPUSD2, which is reliant on mitochondrial integrity for its function in RNA modification. | ||||||
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $54.00 $62.00 $1642.00 $4600.00 | 51 | |
Antimycin A inhibits the mitochondrial complex III, disrupting electron transport and leading to reduced ATP production. This decrease in energy availability can indirectly inhibit the functioning of RPUSD2 within the mitochondria. | ||||||
Oligomycin | 1404-19-9 | sc-203342 sc-203342C | 10 mg 1 g | $146.00 $12250.00 | 18 | |
Oligomycin is an inhibitor of the mitochondrial ATP synthase (complex V), leading to a decrease in ATP production. Without sufficient ATP, mitochondrial processes, including those involving RPUSD2, could be indirectly inhibited. | ||||||
Gentamicin sulfate | 1405-41-0 | sc-203334 sc-203334A sc-203334F sc-203334B sc-203334C sc-203334D sc-203334E | 1 g 5 g 50 g 100 g 1 kg 2.5 kg 7.5 kg | $55.00 $175.00 $499.00 $720.00 $1800.00 $2600.00 $6125.00 | 3 | |
Aminoglycosides cause misreading of mitochondrial mRNA and inhibit mitochondrial protein synthesis. As a result, these antibiotics may indirectly decrease the activity of RPUSD2 by impairing the production of proteins required for its RNA-modifying function. | ||||||
Carbonyl Cyanide m-Chlorophenylhydrazone | 555-60-2 | sc-202984A sc-202984 sc-202984B | 100 mg 250 mg 500 mg | $75.00 $150.00 $235.00 | 8 | |
CCCP uncouples oxidative phosphorylation, leading to a rapid depletion of the mitochondrial membrane potential. This disruption can indirectly inhibit RPUSD2 by affecting the mitochondrial environment essential for its RNA modification activity. | ||||||
Ethidium bromide | 1239-45-8 | sc-203735 sc-203735A sc-203735B sc-203735C | 1 g 5 g 25 g 100 g | $47.00 $147.00 $576.00 $2045.00 | 12 | |
Ethidium Bromide intercalates into DNA and can cause loss of mitochondrial DNA upon prolonged exposure. This can indirectly lead to decreased RPUSD2 activity due to the loss of the mitochondrial genome and its associated functions. | ||||||