Rpp21 Inhibitors
Chemical inhibitors of Rpp21 can affect its role in tRNA processing through various biochemical pathways. Allopurinol inhibits xanthine oxidase, an enzyme vital for purine metabolism, leading to altered nucleotide levels which are crucial substrates for tRNA synthesis, thereby affecting Rpp21 function. Ribavirin and Mycophenolic acid target inosine monophosphate dehydrogenase, reducing the guanine nucleotide pool necessary for tRNA maturation, indirectly impacting Rpp21 activity. Similarly, Tiazofurin's inhibition of the same enzyme can result in reduced synthesis of guanine nucleotides, disrupting the balance of nucleotides required for RNA processing. 5-Fluorouracil incorporates into RNA molecules, interfering with RNA integrity and thus, the RNA processing activity of Rpp21. Methotrexate disrupts dihydrofolate reductase, leading to a shortage in thymidylate and consequently affecting folate-dependent processes, including RNA synthesis and processing where Rpp21 plays a critical role.
Moreover, 6-Mercaptopurine and its prodrug Azathioprine interfere with enzymes in the purine synthesis pathway, their incorporation into nucleic acids can disrupt RNA processing, thus inhibiting Rpp21 function. Cladribine alters DNA synthesis and repair, which can indirectly inhibit Rpp21 by affecting the nucleotide pools. Hydroxyurea targets ribonucleotide reductase, crucial for deoxyribonucleotide supply, and while primarily affecting DNA synthesis, it can also have consequences for RNA processing pathways involving Rpp21. Clofarabine and Fludarabine, purine nucleoside analogs, inhibit ribonucleotide reductase and DNA polymerases, leading to inhibition of DNA repair and replication, which in turn can affect Rpp21's involvement in RNA processing due to changes in cellular nucleotide pools. These diverse chemical inhibitors, through their distinct biochemical interactions, demonstrate the intricate relationship between nucleotide synthesis and availability with the functional role of Rpp21 in tRNA processing.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Allopurinol | 315-30-0 | sc-207272 | 25 g | $128.00 | ||
Rpp21 is involved in the processing of precursor tRNA and allopurinol inhibits xanthine oxidase, an enzyme in the purine metabolism pathway. By inhibiting this pathway, allopurinol can lead to altered levels of nucleotides, thereby potentially affecting the substrates available for tRNA synthesis and indirectly inhibiting Rpp21 function. | ||||||
Ribavirin | 36791-04-5 | sc-203238 sc-203238A sc-203238B | 10 mg 100 mg 5 g | $62.00 $108.00 $210.00 | 1 | |
Ribavirin is a nucleoside inhibitor that can inhibit inosine monophosphate dehydrogenase, thereby depleting the intracellular guanine pool. Since Rpp21 is involved in tRNA processing, a shortage of guanine nucleotides could inhibit the proper functioning of Rpp21 by limiting the necessary components for tRNA maturation. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
This compound is a pyrimidine analog that interferes with RNA processing by incorporating into RNA molecules. As Rpp21 is a ribonuclease component of RNase P complex, which processes RNA molecules, the presence of 5-Fluorouracil can inhibit the RNA processing activity of Rpp21 by disrupting RNA integrity. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
Methotrexate acts by inhibiting dihydrofolate reductase, which leads to a deficiency in thymidylate and other folate-dependent processes. This perturbation in folate metabolism can impact the synthesis and processing of RNA, thus indirectly inhibiting the function of Rpp21 in tRNA maturation. | ||||||
6-Mercaptopurine | 50-44-2 | sc-361087 sc-361087A | 50 mg 100 mg | $71.00 $102.00 | ||
6-Mercaptopurine is a purine analog that inhibits several enzymes in the purine synthesis pathway. Its incorporation into nucleic acids can disrupt RNA processing, potentially inhibiting the function of Rpp21 as this protein is critical for the maturation of precursor tRNAs. | ||||||
Azathioprine | 446-86-6 | sc-210853D sc-210853 sc-210853A sc-210853B sc-210853C | 500 mg 1 g 2 g 5 g 10 g | $199.00 $173.00 $342.00 $495.00 $690.00 | 1 | |
Azathioprine is metabolized into 6-mercaptopurine. It can cause a reduction in the synthesis of purine nucleotides, therefore indirectly inhibiting Rpp21 by impacting the availability of substrates required for its role in tRNA processing. | ||||||
2-Chloro-2′-deoxyadenosine | 4291-63-8 | sc-202399 | 10 mg | $144.00 | 1 | |
Cladribine is a purine nucleoside analog that disrupts DNA synthesis and repair. By altering the nucleotide pools, it can indirectly inhibit Rpp21's role in tRNA processing because the altered nucleotide balance can affect RNA synthesis and maturation. | ||||||
Mycophenolic acid | 24280-93-1 | sc-200110 sc-200110A | 100 mg 500 mg | $68.00 $261.00 | 8 | |
Mycophenolic acid inhibits inosine monophosphate dehydrogenase, leading to decreased de novo synthesis of guanosine nucleotides. This reduction can indirectly inhibit the function of Rpp21 as it could limit the availability of essential nucleotides for the maturation of precursor tRNAs. | ||||||
Tiazofurin | 60084-10-8 | sc-475805 | 5 mg | $440.00 | ||
Tiazofurin is an adenosine analog that inhibits inosine monophosphate dehydrogenase. This can lead to reduced guanine nucleotide synthesis, indirectly inhibiting the function of Rpp21 by affecting the pool of nucleotides necessary for RNA processing. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Hydroxyurea inhibits ribonucleotide reductase, leading to a decreased supply of deoxyribonucleotides. While its primary action is on DNA synthesis, the consequent disturbance in nucleotide pools can indirectly inhibit Rpp21 by affecting RNA processing pathways. | ||||||