Molecular structure of 2-Chloro-2′-deoxyadenosine, CAS Number: 4291-63-8
2-Chloro-2′-deoxyadenosine (CAS 4291-63-8)
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Alternate Names:
Cladribine; 2CdA
Application:
2-Chloro-2′-deoxyadenosine is an apoptosis inducer
CAS Number:
4291-63-8
Purity:
≥99%
Molecular Weight:
285.7
Molecular Formula:
C10H12ClN5O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
2-Chloro-2′-deoxyadenosine is a deoxyadenosine analog that induces apoptosis in chronic lymphocytic leukemia (CLL) cells. Studies show that 2-chloro-2′-deoxyadenosine can be produced from intact cells of Escherichia coli that produce B-2194 thermostable purine-nucleoside phosphorylase II. In addition, in vitro studies show that 2-Chloro-2′-deoxyadenosine can inhibit human T and B cell lymphoproliferative responses possibly by inhibiting DNA repair. Furthermore, Staphylococcus aureus Cowan-induced expression of CD25 on B-cells is suppressed by 2-Chloro-2′-deoxyadenosine.
2-Chloro-2′-deoxyadenosine (CAS 4291-63-8) References
- Cladribine activity in systemic mast cell disease: application of biochemistry in the modern era of molecular biology. | Nieva, J. and Saven, A. 2004. Leuk Res. 28: 113-4. PMID: 14654073
- [Synthesis of 2-chloro-2'-deoxyadenosine by microbiological transglycosylation using a recombinant Escherichia coli strain]. | Taran, SA., et al. 2008. Prikl Biokhim Mikrobiol. 44: 181-6. PMID: 18669260
- Beyond hairy cell: the activity of cladribine in other hematologic malignancies. | Sigal, DS., et al. 2010. Blood. 116: 2884-96. PMID: 20634380
- Cladribine: mode of action and implications for treatment of multiple sclerosis. | Leist, TP. and Weissert, R. 2011. Clin Neuropharmacol. 34: 28-35. PMID: 21242742
- Potential mechanisms of action related to the efficacy and safety of cladribine. | Baker, D., et al. 2019. Mult Scler Relat Disord. 30: 176-186. PMID: 30785074
- Adenosine Signaling in Glioma Cells. | Ceruti, S. and Abbracchio, MP. 2020. Adv Exp Med Biol. 1202: 13-33. PMID: 32034707
- The development and impact of cladribine on lymphoid and myeloid cells in multiple sclerosis. | Voo, VTF., et al. 2021. Mult Scler Relat Disord. 52: 102962. PMID: 33901971
- B cells in multiple sclerosis - from targeted depletion to immune reconstitution therapies. | Cencioni, MT., et al. 2021. Nat Rev Neurol. 17: 399-414. PMID: 34075251
- Reviewing the Significance of Blood-Brain Barrier Disruption in Multiple Sclerosis Pathology and Treatment. | Balasa, R., et al. 2021. Int J Mol Sci. 22: PMID: 34445097
- Erdheim-Chester disease. | Brychtová, M., et al. 2021. Klin Onkol. 34: 434-439. PMID: 34911328
- Mass cytometry reveals cladribine-induced resets among innate lymphoid cells in multiple sclerosis. | Aglas-Leitner, FT., et al. 2022. Sci Rep. 12: 20411. PMID: 36437270
- Cladribine for the treatment of hematologic malignancies. | Baltz, JK. and Montello, MJ. 1993. Clin Pharm. 12: 805-13; quiz 860-2. PMID: 7903917
- Cladribine (2-chloro-deoxyadenosine, CDA): an inhibitor of human B and T cell activation in vitro. | Górski, A., et al. 1993. Immunopharmacology. 26: 197-202. PMID: 7904595
Inhibitor of:
6030422M02Rik, Ada2, Adad2, ADAR3, ADAT3, Adenosine deaminase, AdSS1, AI481877, AMDHD2, AMPD1, APOBEC4, APRT, Atase, BAT5, BST-1, C6orf167, CMPK2, CNT1, dCK, DERA, DGUOK, DNA pol α, DNA pol δ cat, dNT-1, DTYMK, GlyRS, GMPR1, GMPR2, GUCD1, GUK1, Hairy Cell Leukemia Marker, HISPPD2A, Histone cluster 1 H2AF, HPRT, ISYNA1, MGP, NASP, Nucleoside Monophosphate Kinase, NUDC, PAPST2, PD-ECGF, PIG-YL, PNP2, Ppat, PRIM1, PRPS1L1, PRPS3, PRPSAP1, PRPSAP2, PRTFDC1, PUSL1, R2, RNase Z1, Rpp21, SAMHD1, SGS3, SLC29 (solute carrier family 29), Trav12n-1, UCK1, UPase 2, WC1, and XTP3TPA.Activator of:
ADK, ADO, CDD, ITPase, NUDT15, UBE1L2, and UMPS.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2-Chloro-2′-deoxyadenosine, 10 mg | sc-202399 | 10 mg | $144.00 |