Rpp20 Inhibitors
Chemical inhibitors of Rpp20 can obstruct its role in RNA processing through various molecular mechanisms. Alloxan, for instance, generates oxidative stress that can selectively inhibit RNA processing enzymes. This oxidative environment can disrupt the molecular functionality of Rpp20, impeding its ability to properly process RNA. Similarly, Aurintricarboxylic Acid can hinder Rpp20's function by inhibiting nucleases that are essential for RNA maturation, thus preventing Rpp20 from performing its role in the RNA processing pathways. Ethidium Bromide, which intercalates into RNA, can inhibit Rpp20's RNA processing activities by blocking Rpp20's access to its RNA substrates.
In addition, Actinomycin D binds tightly to the DNA at the transcription initiation complex, stopping RNA polymerase in its tracks and thus preventing the elongation of RNA molecules that Rpp20 would typically process. α-Amanitin inhibits RNA polymerase II, leading to a reduction in mRNA synthesis and thereby limiting the functional role of Rpp20 due to a lack of RNA substrate. Leptomycin B, which inhibits the export of RNA from the nucleus, can also limit the availability of RNA molecules for Rpp20 to process in the cytoplasm. Ribavirin reduces guanosine triphosphate pools, which can influence guanosine-dependent RNA processing pathways and inhibit Rpp20's activity. Cordycepin acts as a chain terminator during RNA synthesis, resulting in premature termination and a subsequent reduction in mature RNA substrates for Rpp20 to process. Moreover, DRB blocks the phosphorylation of RNA polymerase II, which is essential for the transcription process, thereby decreasing the pool of RNA molecules for Rpp20. Lastly, Tunicamycin and Distamycin A, though not directly targeting Rpp20, can alter the cellular environment in ways that reduce the efficiency of RNA processing, indirectly affecting Rpp20's function. Tunicamycin does this by inhibiting glycosylation, while Distamycin A binds to DNA, affecting transcription factors and DNA-associated enzymes. Camptothecin's inhibition of DNA topoisomerase I leads to DNA damage that can affect transcription processes, thus indirectly inhibiting the function of Rpp20 by reducing the availability of RNA molecules for processing.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Alloxan monohydrate | 2244-11-3 | sc-254940 | 10 g | $53.00 | ||
Alloxan can induce a selective inhibition of RNA processing enzymes due to its oxidative mechanisms. As Rpp20 is involved in RNA processing, the oxidative stress caused by Alloxan can disrupt the function of Rpp20 by altering its molecular environment. | ||||||
Aurintricarboxylic Acid | 4431-00-9 | sc-3525 sc-3525A sc-3525B sc-3525C | 100 mg 1 g 5 g 10 g | $20.00 $31.00 $47.00 $92.00 | 13 | |
This chemical can inhibit nucleases and therefore can interfere with RNA processing pathways in which Rpp20 is involved. By inhibiting the enzymes that are responsible for the maturation of RNA molecules, Aurintricarboxylic Acid can impede the functional role of Rpp20 in these pathways. | ||||||
Ethidium bromide | 1239-45-8 | sc-203735 sc-203735A sc-203735B sc-203735C | 1 g 5 g 25 g 100 g | $47.00 $147.00 $576.00 $2045.00 | 12 | |
Ethidium Bromide can intercalate into RNA molecules, potentially inhibiting the RNA processing activities where Rpp20 is implicated. This binding can disrupt the proper functioning of Rpp20 by blocking its access to RNA substrates. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D binds to DNA at the transcription initiation complex and prevents elongation of RNA by RNA polymerase. This binding can inhibit the formation of RNA substrates with which Rpp20 interacts during RNA processing. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
α-Amanitin is a potent inhibitor of RNA polymerase II and can inhibit the transcription of mRNAs. As Rpp20 is associated with the processing of RNA, the reduced synthesis of RNA molecules can inhibit the functional requirements for Rpp20. | ||||||
Leptomycin B | 87081-35-4 | sc-358688 sc-358688A sc-358688B | 50 µg 500 µg 2.5 mg | $105.00 $408.00 $1224.00 | 35 | |
Leptomycin B inhibits the export of RNA molecules from the nucleus by binding to exportin 1. This action can inhibit the role of Rpp20 in RNA processing by limiting the availability of RNA molecules that require processing in the cytoplasm. | ||||||
Ribavirin | 36791-04-5 | sc-203238 sc-203238A sc-203238B | 10 mg 100 mg 5 g | $62.00 $108.00 $210.00 | 1 | |
Ribavirin is a nucleoside analogue that can inhibit inosine monophosphate dehydrogenase, leading to a depletion of guanosine triphosphate pools. This can influence RNA processing pathways dependent on guanosine-containing molecules, thereby inhibiting Rpp20's activity. | ||||||
Cordycepin | 73-03-0 | sc-203902 | 10 mg | $99.00 | 5 | |
Cordycepin (3'-deoxyadenosine) acts as a chain terminator during RNA synthesis. This premature termination can inhibit the RNA processing functions of Rpp20 by reducing the number of RNA molecules that reach maturity and thus require processing. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $42.00 $185.00 $310.00 $650.00 | 6 | |
DRB is an adenosine analogue that inhibits RNA polymerase II by blocking the phosphorylation of the C-terminal domain of the largest subunit of RNA polymerase II. This inhibition results in a reduction of RNA substrates available for Rpp20, thereby decreasing its functional activity. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Tunicamycin inhibits N-linked glycosylation by blocking the first step in the synthesis of the lipid-linked oligosaccharide precursor. While Rpp20 is not a glycoprotein, the inhibition of glycosylation can disrupt the overall cellular environment and indirectly inhibit the processing of RNA molecules, thereby affecting the function of Rpp20. | ||||||