Tunicamycin CAS: 11089-65-9
MF: C38H62N4O16 (Tun B)
MW: 840.0 (Avg.)

Tunicamycin (CAS 11089-65-9)

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Tunicamycin is rated 4.5 out of 5 by 2.
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Alternative Namen: Tunicamycin also known as nucleoside antibiotic
Anwendungen Tunicamycin is a competitive cell cycle inhibitor exhibiting antiungal properties and is widely used in the study of glycoprotein synthesis
CAS Nummer: 11089-65-9
Reinheit: ≥99% (total complex)
Molekulargewicht: 840.0 (Avg.)
Summenformel: C38H62N4O16 (Tun B)
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
Ausschließlich für Forschungszwecke. Nicht Geeignet für Verwendung in Diagnostik oder Therapie.
* Schauen Sie auf das Analysezertifikat (CoA), um die genauen Daten (inkl. Wassergehalt) Ihrer Produktionscharge (Lot) zu sehen.

Tunicamycin is a mixture of tunicamycins A, B, C and D and has been widely used in the study of glycoprotein synthesis in various biological systems. Tunicamycin inhibits GlcNAc phosphotransferase (GPT) and inhibts the formation of N-glycosidic linkages in glycoprotein sunthesis. Tunicamycin has also been reported to have a dose-dependent inhibition of DNA synthesis, inhibit protein glycosylation, suppression of the S phase and to also arrest the cell cycle in late G1. As a member of a family of antibiotics produced by Streptomyces lysosuperficus, tunicamycin is noted to be active in vitro against gram-positive bacteria, fungi, yeasts and viruses. During protein glycosylation, tunicamycin is noted to be an inhibitor of the transfer of saccharide moieties to dolichol during dolichol-linked glycoprotein synthesis. Through this mechanism, it has been postulated to arrest cell cycling as a competitive inhibitor of glycoprotein synthesis. Dose-dependent inhibition of DNA synthesis may be related to the alteration of glycoproteins which thereby affect the transport of thymidine into cells. Additionally, tunicamycin has been reported to prevent cell cycle progression in primary cultures of rat glial cells as well as inhibit lipid-mediated protein glycosylation in chick or mouse fibroblasts in a dose-dependent manner.


Literaturhinweise

1. Duksin, D., et al. 1982. J. Biol. Chem. 257: 3105-3109. PMID: 7061468

2. Langan, T.J. and Slater, M.C. 1991. J. Cell Physiol. 149: 284-292. PMID: 1748720

3: Ishii, S. and Volpe, J.J. 1987. J. Neurochem 49: 1606-1612. PMID: 3668542

Aggregatzustand :
Solid
Erhaltene Form :
Streptomyces sp.
Löslichkeit :
Soluble in water (partly miscible), alkaline water, pyridine, hot methanol, DMSO (>10 mg/ml), ethanol (5 mg/ml), butanol (slightly), and DMF. Insoluble in acetone, ethyl acetate, chloroform, benzene, and acidic water.
LAGERUNG: :
Store at room temperature
Ausschließlich für Forschungszwecke. Nicht Geeignet für Verwendung in Diagnostik oder Therapie.
Deutsche WGK :
3
RTECS :
YO7980200
Merck Index :
14: 9819
MDL-Nummer :
MFCD00065709
Beilstein-Registernummer :
6888090

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Analysenzertifikat

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Tunicamycin (CAS 11089-65-9)  Publikationen

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PMID: # 30100737  Chen, J. et al. 2018. Onco Targets Ther. 11: 4315-4325.

PMID: # 28953979  English, BC. et al. 2017. PLoS Pathog. 13: e1006589.

PMID: # 29074567  Gendarme, M. et al. 2017. Mol. Biol. Cell.

PMID: # 28981087  van Raam, BJ. et al. 2017. Cell Death Dis. 8: e3069.

PMID: # 29118074  Baumann, J. et al. 2017. Mol. Biol. Cell.

PMID: # 28536105  Ramírez-Peinado, S. et al. 2017. J. Cell. Sci. 130: 2251-2265.

PMID: # 25903460  Kim, AY. et al. 2015. BMC Genomics. 16: 338.

PMID: # 26040720  Khaminets, A. et al. 2015. Nature. 522: 354-8.

PMID: # 25824232  Li, R. et al. 2015. Antimicrob. Agents Chemother. 59: 3460-8.

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