Rpb7 Activators
Rpb7 activators represent an array of chemical compounds that specifically enhance the activity of the Rpb7 protein, a subunit involved in the assembly and function of RNA polymerase II, crucial for the transcription of DNA into messenger RNA. These activators are designed to target the pathways that Rpb7 is directly involved in, aiming to amplify its inherent role in the transcription machinery. For instance, certain small molecule activators may bind to allosteric sites on the Rpb7 subunit, inducing conformational changes that increase its affinity for the RNA polymerase II complex, thereby stabilizing the assembly or enhancing its interaction with RNA. Other chemicals in this class might interact with the phosphorylation process that regulates the activity of Rpb7, promoting its active form and ensuring a more robust transcriptional response. The precise action of these compounds involves intricate interactions with the molecular structure of Rpb7, ensuring that they do not merely increase the expression of the Rpb7 gene but instead directly bolster the protein's functional capacity within the transcription apparatus.
The biochemical mechanisms by which Rpb7 activators exert their effects are diverse, reflecting the complexity of transcriptional regulation. Some activators might modulate the interaction between Rpb7 and other transcriptional coactivators or corepressors, enhancing the recruitment of essential transcription factors and, therefore, the initiation of gene transcription. Others could affect the rate of transcription elongation by stabilizing the Rpb7 protein within the RNA polymerase II complex during the rapid and processive copying of genetic information. This stabilization could reduce transcriptional errors and increase the efficiency of mRNA synthesis. Rpb7 activators thus represent a targeted approach to upregulate the transcriptional throughput at a fundamental level, providing a means to enhance the protein's activity without altering gene expression or relying on the upregulation of ancillary pathways. Taken together, these activators focus on maximizing the functional performance of Rpb7 within its native role in the cell, ensuring that the protein's activity is carried out with greater vigor and precision.
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin increases intracellular cAMP levels, which in turn activates PKA. PKA can phosphorylate various substrates that could interact with Rpb7, as part of the RNA polymerase II complex, potentially enhancing its role in mRNA synthesis and processing. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4 (PDE4), leading to an increase in cAMP levels in cells. Elevated cAMP can activate protein kinase A (PKA), which may enhance the phosphorylation status of RNA polymerase II and its associated factor Rpb7, increasing transcriptional activity. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
Sphingosine-1-phosphate functions as a signaling lipid that can activate a cascade of kinases, potentially affecting transcription machinery. This could enhance the activity of Rpb7 by modulating its interaction with the core RNA polymerase II complex. | ||||||
Ciglitazone | 74772-77-3 | sc-200902 sc-200902A | 5 mg 25 mg | $104.00 $428.00 | 10 | |
Ciglitazone is a PPARγ agonist which, upon activation, can influence a wide array of genes including those involved in transcriptional regulation. Through PPARγ activation, ciglitazone may alter the transcription machinery, indirectly enhancing Rpb7's functional activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is an activator of protein kinase C (PKC) which can phosphorylate substrates that may interact with Rpb7, potentially promoting its role in transcriptional regulation as a part of the RNA polymerase II complex. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, activating calcium-dependent protein kinases which could indirectly enhance Rpb7 activity by modulating its association with RNA polymerase II. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is known to inhibit several kinases; this could reduce competitive signaling pathways, indirectly enhancing the pathways that involve Rpb7 and thus its function in RNA synthesis. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor that can alter downstream AKT signaling, which may have a role in transcriptional regulation. This could indirectly enhance Rpb7's activity by affecting its interaction with the RNA polymerase II complex. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a p38 MAPK inhibitor which can alter the activation state of transcription factors and potentially increase Rpb7's transcriptional activity by modulating RNA polymerase II-dependent gene expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates SIRT1, an NAD+-dependent deacetylase, which is known to deacetylate and affect factors involved in transcription. This could enhance Rpb7 activity by modulating the RNA polymerase II complex's interaction with chromatin. | ||||||