Rpb7 Inhibitors
The chemical class known as Rpb7 inhibitors belongs to a group of compounds that are characterized by their ability to selectively target and interact with the Rpb7 protein. Rpb7 is a crucial subunit of RNA polymerase II, an enzyme responsible for transcription in eukaryotic cells. The inhibition of Rpb7 involves the disruption of its normal function within the transcription machinery. These inhibitors are designed to modulate transcription processes by specifically binding to the Rpb7 subunit, thereby affecting the overall transcriptional activity.
The structural features and mechanisms of action of Rpb7 inhibitors can vary, but their common objective is to interfere with the functioning of Rpb7, which in turn could influence the dynamics of RNA polymerase II-mediated transcription. Research into Rpb7 inhibitors may contribute to a deeper understanding of transcription regulation and offer insights into the development of compounds that can specifically influence transcriptional processes.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
Inhibits RNA polymerase II by binding to the Rpb1 subunit, blocking transcription elongation. | ||||||
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $97.00 $328.00 $676.00 $1467.00 | 6 | |
Binds to the β subunit of bacterial RNA polymerase, inhibiting RNA synthesis in prokaryotes. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Forms DNA adducts, disrupting DNA replication and transcription, affecting RNA polymerase activity. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Binds to DNA, preventing RNA synthesis by inhibiting RNA polymerase movement along the DNA strand. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $259.00 | 41 | |
Selective inhibitor of cyclin-dependent kinases (CDKs), indirectly affecting RNA polymerase function. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Inhibits RNA polymerase II transcription by disrupting the assembly of transcription initiation complex. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $43.00 $189.00 $316.00 $663.00 | 6 | |
Inhibits transcription by targeting the Rpb1 subunit of RNA polymerase II. | ||||||
BMH-21 | 896705-16-1 | sc-507460 | 10 mg | $165.00 | ||
Binds to the secondary channel of RNA polymerase II, inhibiting transcription initiation. | ||||||