RPA135 Activators

The class of POLR1B activators comprises a diverse range of chemical compounds primarily influencing transcriptional regulation and chromatin remodeling, potentially modulating the activity of POLR1B, a subunit of RNA polymerase I. This group includes DNA methyltransferase inhibitors like 5-Azacytidine and histone deacetylase inhibitors such as Trichostatin A and Sodium Butyrate. These compounds can lead to changes in chromatin structure, enhancing transcriptional activity and potentially upregulating POLR1B's role in rRNA transcription.

Compounds like Retinoic Acid and Vitamin D3, known for their roles in modulating gene expression, are included for their potential impact on transcriptional processes that could influence POLR1B activity. Forskolin, by increasing cAMP levels, and Curcumin, with its broad effects on cellular signaling, could also modulate transcription regulation processes involving POLR1B. Resveratrol, with its effects on metabolic pathways, might indirectly impact POLR1B activity by modulating cellular metabolic and signaling pathways. Additionally, antioxidants like Quercetin and Epigallocatechin Gallate (EGCG) are part of this class for their potential role in influencing transcription regulation through pathways related to oxidative stress and inflammation. Niacin, due to its role in cellular metabolism, is included for its potential indirect influence on POLR1B activity through metabolic pathways.