RNF11 Activators
RNF11, also known as RING finger protein 11, is a member of the RING (really interesting new gene) finger family of E3 ubiquitin ligases. This protein plays a crucial role in various cellular processes, including ubiquitination-mediated protein degradation, signal transduction, and immune responses. RNF11 has been implicated in the regulation of several signaling pathways, such as NF-κB, EGFR, and TGF-β, highlighting its significance in cellular homeostasis and disease pathogenesis.
Activation of RNF11 can be achieved through various mechanisms involving intracellular signaling pathways. For instance, compounds like forskolin and PMA stimulate adenylate cyclase and protein kinase C, respectively, leading to downstream signaling events that may activate RNF11 through phosphorylation or other post-translational modifications. Additionally, calcium ionophores like ionomycin and A23187 elevate intracellular calcium levels, potentially triggering calcium-dependent signaling cascades that intersect with RNF11-associated pathways, thereby promoting its functional activation. Furthermore, agents like Thapsigargin and Bay K8644 modulate calcium homeostasis, indirectly influencing RNF11 activation through their effects on calcium-dependent signaling networks. These diverse mechanisms underscore the multifaceted nature of RNF11 regulation and its intricate involvement in cellular physiology.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, leading to increased levels of cyclic AMP (cAMP), which activates protein kinase A. This kinase phosphorylates and activates various cellular proteins, potentially including RNF11. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC) by mimicking diacylglycerol (DAG), leading to downstream signaling events that may activate RNF11, possibly through phosphorylation-mediated mechanisms. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
Ionomycin increases intracellular calcium levels, which can activate calcium-dependent signaling pathways. These pathways may intersect with those involving RNF11, leading to its functional activation. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187, similar to ionomycin, is a calcium ionophore that elevates intracellular calcium levels, potentially activating calcium-dependent signaling cascades that could involve RNF11 in cellular processes. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin inhibits the sarco/endoplasmic reticulum Ca^2+-ATPase (SERCA) pump, leading to depletion of ER calcium stores and subsequent calcium influx, potentially activating calcium-dependent pathways that modulate RNF11 function. | ||||||
Phorbol-12,13-dibutyrate | 37558-16-0 | sc-202285 | 1 mg | $124.00 | 3 | |
PDBu activates protein kinase C (PKC) directly, leading to downstream signaling events that may involve RNF11 activation through phosphorylation or other PKC-mediated mechanisms. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $84.00 $196.00 $817.00 | ||
Bay K8644 is a calcium channel activator that enhances calcium influx into cells. This increased calcium concentration may trigger signaling pathways that contribute to the activation of RNF11. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
BAPTA-AM is a calcium chelator that reduces intracellular calcium levels. Inhibition of calcium-dependent signaling pathways by BAPTA-AM may indirectly affect RNF11 activation, as calcium signaling is involved in various cellular processes. | ||||||
L-NG-Nitroarginine Methyl Ester (L-NAME) | 51298-62-5 | sc-200333 sc-200333A sc-200333B | 1 g 5 g 25 g | $48.00 $107.00 $328.00 | 45 | |
L-NAME inhibits nitric oxide synthase (NOS), which results in reduced nitric oxide (NO) production. As NO signaling can modulate various cellular pathways, including those possibly involving RNF11, its inhibition by L-NAME may lead to RNF11 activation. | ||||||
NS-1619 | 153587-01-0 | sc-200986 | 5 mg | $133.00 | 2 | |
NS1619 is an activator of large-conductance calcium-activated potassium channels (BKCa). Activation of BKCa channels by NS1619 can influence intracellular calcium levels, potentially leading to RNF11 activation through calcium-dependent signaling pathways. | ||||||