RNF11 Antibody (4G7): sc-517151
- RNF11 Antibody (4G7) is a mouse monoclonal IgG2a κ RNF11 antibody provided at 50 µg/0.5 ml
- raised against amino acids 65-154 representing partial length RNF11 of human origin
- recommended for detection of RNF11 of mouse, rat and human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for RNF11 Antibody (4G7). This work is in progress.
RNF11 Antibody (4G7) is a mouse monoclonal IgG2a kappa light chain antibody that detects RNF11 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-RNF11 antibody (4G7) is available as the non-conjugated format. RNF11, also known as RING finger protein 11 or CGI-123, is a 154 amino acid protein characterized by a RING-type zinc finger motif, which is crucial for function in the ubiquitination pathway of protein degradation. This motif consists of a conserved cysteine-rich domain capable of binding two zinc ions, a feature essential for structural integrity and functional activity of RNF11. RNF11′s ability to interact with key proteins such as NEDD4, an E3 ubiquitin-protein ligase, and epidermal growth factor receptor (EGFR) highlights RNF11′s role in regulating various cellular processes, including signal transduction and protein turnover. By modulating activity of growth-associated proteins like EGFR, RNF11 is implicated in pathogenesis of several diseases, including endocrine neoplasia, Parkinson′s disease, and breast cancer, making RNF11 a significant target for research in cancer biology and neurodegenerative disorders.
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RNF11 Antibody (4G7) References:
- Cloning and expression profile of mouse and human genes, Rnf11/RNF11, encoding a novel RING-H2 finger protein. | Seki, N., et al. 1999. Biochim Biophys Acta. 1489: 421-7. PMID: 10673045
- Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4. | Jolliffe, CN., et al. 2000. Biochem J. 351 Pt 3: 557-65. PMID: 11042109
- The RING-H2 protein RNF11 is differentially expressed in breast tumours and interacts with HECT-type E3 ligases. | Kitching, R., et al. 2003. Biochim Biophys Acta. 1639: 104-12. PMID: 14559117
- The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase. | Subramaniam, V., et al. 2003. Br J Cancer. 89: 1538-44. PMID: 14562029
- An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein. | Li, H. and Seth, A. 2004. Oncogene. 23: 1801-8. PMID: 14755250
- Molecular characterization of ring finger protein 11. | Connor, MK., et al. 2005. Mol Cancer Res. 3: 453-61. PMID: 16123141
- Novel RING E3 ubiquitin ligases in breast cancer. | Burger, A., et al. 2006. Neoplasia. 8: 689-95. PMID: 16925951
- PARK10 candidate RNF11 is expressed by vulnerable neurons and localizes to Lewy bodies in Parkinson disease brain. | Anderson, LR., et al. 2007. J Neuropathol Exp Neurol. 66: 955-64. PMID: 17917589
- The WW domain containing E3 ubiquitin protein ligase 1 upregulates ErbB2 and EGFR through RING finger protein 11. | Chen, C., et al. 2008. Oncogene. 27: 6845-55. PMID: 18724389
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RNF11 Antibody (4G7) | sc-517151 | 50 µg/0.5 ml | $322.00 |