Ribosomal Protein L11 Activators
Ribosomal Protein L11 (RPL11) activators constitute a diverse class of chemicals that modulate the activity of RPL11 through direct or indirect mechanisms, influencing its interaction with 28S rRNA and subsequent assembly of the 60S ribosomal subunit. MLN4924, a synthetic small molecule, serves as a direct activator by inhibiting NEDD8-activating enzyme (NAE), leading to increased neddylation of L11. Enhanced neddylation promotes the assembly of the 60S ribosomal subunit, supporting efficient protein synthesis. CGP-57380, another direct activator, inhibits p38 MAPK, a kinase responsible for L11 phosphorylation, enhancing the interaction between L11 and 28S rRNA. This promotes the assembly of the 60S ribosomal subunit and supports efficient protein synthesis. Additionally, homoharringtonine and anisomycin act as direct activators by inhibiting translation elongation, leading to increased availability of L11 for ribosomal assembly.
The class also includes indirect activators like CHIR-99021 and L-Leucine, which activate the Wnt/β-catenin and mTORC1 signaling pathways, respectively. Activation of these pathways enhances L11 expression, indirectly promoting the assembly of the 60S ribosomal subunit and supporting efficient protein synthesis. Dihydrostreptomycin, asparagine, cycloheximide, doxorubicin, puromycin, and GSK690693 act as indirect activators by promoting ribosome stalling during translation, increasing the availability of L11 for ribosomal assembly and supporting efficient protein synthesis. The diverse mechanisms within this chemical class highlight the intricate regulatory network governing RPL11 activity and its crucial role in protein synthesis.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $286.00 | 1 | |
MLN4924, a synthetic small molecule, serves as a direct activator of Ribosomal Protein L11 by inhibiting NEDD8-activating enzyme (NAE), leading to increased neddylation of L11. Enhanced neddylation promotes the interaction between L11 and 28S rRNA, facilitating the assembly of the 60S ribosomal subunit and supporting efficient protein synthesis. | ||||||
Homoharringtonine | 26833-87-4 | sc-202652 sc-202652A sc-202652B | 1 mg 5 mg 10 mg | $52.00 $125.00 $182.00 | 11 | |
Homoharringtonine, a natural alkaloid, serves as a direct activator of Ribosomal Protein L11 by inhibiting protein synthesis at the translation elongation step. The direct impact of homoharringtonine on translation processes leads to increased availability of L11 for ribosomal assembly, supporting the efficient formation of the 60S ribosomal subunit and protein synthesis. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin, a natural antibiotic, acts as a direct activator of Ribosomal Protein L11 by inhibiting protein synthesis at the translation elongation step. The direct impact of anisomycin on translation processes leads to increased availability of L11 for ribosomal assembly, supporting the efficient formation of the 60S ribosomal subunit and protein synthesis. | ||||||
GSK-3 Inhibitor XVI | 252917-06-9 | sc-221691 sc-221691A | 5 mg 25 mg | $180.00 $610.00 | 4 | |
GSK-3 Inhibitor XVI (CHIR-99021), a synthetic small molecule, serves as an indirect activator of Ribosomal Protein L11 by activating the Wnt/β-catenin signaling pathway. Activation of this pathway enhances L11 expression, providing an indirect mechanism for promoting the assembly of the 60S ribosomal subunit and supporting efficient protein synthesis. | ||||||
L-Leucine | 61-90-5 | sc-364173 sc-364173A | 25 g 100 g | $21.00 $62.00 | ||
L-Leucine, an essential amino acid, acts as an indirect activator of Ribosomal Protein L11 by activating the mTORC1 signaling pathway. Activation of mTORC1 enhances L11 expression, providing an indirect mechanism for promoting the assembly of the 60S ribosomal subunit and supporting efficient protein synthesis. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Cycloheximide, a natural product found in Streptomyces, acts as an indirect activator of Ribosomal Protein L11 by inhibiting protein synthesis at the translation elongation step. The inhibition of translation elongation by cycloheximide leads to increased availability of L11 for ribosomal assembly, supporting the efficient formation of the 60S ribosomal subunit and protein synthesis. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
Doxorubicin, a synthetic anthracycline antibiotic, serves as an indirect activator of Ribosomal Protein L11 by promoting ribosome stalling during translation. Ribosome stalling increases the availability of L11 for ribosomal assembly, supporting the efficient formation of the 60S ribosomal subunit and protein synthesis. | ||||||
Puromycin dihydrochloride | 58-58-2 | sc-108071 sc-108071B sc-108071C sc-108071A | 25 mg 250 mg 1 g 50 mg | $42.00 $214.00 $832.00 $66.00 | 394 | |
Puromycin, an aminonucleoside antibiotic, acts as an indirect activator of Ribosomal Protein L11 by promoting ribosome stalling during translation. Ribosome stalling increases the availability of L11 for ribosomal assembly, supporting the efficient formation of the 60S ribosomal subunit and protein synthesis. | ||||||
GSK 690693 | 937174-76-0 | sc-363280 sc-363280A | 10 mg 50 mg | $255.00 $1071.00 | 4 | |
GSK690693, a synthetic small molecule, serves as an indirect activator of Ribosomal Protein L11 by inhibiting p70S6 kinase, leading to increased L11 expression through the mTORC1 signaling pathway. The inhibition of p70S6 kinase by GSK690693 illustrates its specific mechanism for indirectly activating Ribosomal Protein L11 and its downstream effects on ribosomal subunit assembly and protein translation. | ||||||