Molecular structure of GSK 690693, CAS Number: 937174-76-0
GSK 690693 (CAS 937174-76-0)
See product citations (4)
Alternate Names:
4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy)-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol
Application:
GSK 690693 is an ATP-competitive pan-Akt kinase inhibitor with potential antiproliferative and apoptotic effects
CAS Number:
937174-76-0
Purity:
≥98%
Molecular Weight:
425.48
Molecular Formula:
C21H27N7O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
GSK 690693 is an aminofurazan-derived, low-nanomolar, ATP-competitive pan-Akt kinase inhibitor (IC50 values: Akt1 = 2 nM, Akt2 = 13 nM and Akt3 = 9 nM). GSK 690693 also exhibits some inhibition for AMPK, PKA and PAK and PKC isoforms (IC50 < 100 nM). GSK 690693 has been shown to producte antiproliferative and apoptotic effects in tumor cell lines.
GSK 690693 (CAS 937174-76-0) References
- Characterization of an Akt kinase inhibitor with potent pharmacodynamic and antitumor activity. | Rhodes, N., et al. 2008. Cancer Res. 68: 2366-74. PMID: 18381444
- Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase. | Heerding, DA., et al. 2008. J Med Chem. 51: 5663-79. PMID: 18800763
- Combined ampakine and BDNF treatments enhance poststroke functional recovery in aged mice via AKT-CREB signaling. | Clarkson, AN., et al. 2015. J Cereb Blood Flow Metab. 35: 1272-9. PMID: 25757752
- A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. | Lee, TD., et al. 2019. Mol Pharmacol. 96: 629-640. PMID: 31515284
- Context-Specific Efficacy of Apalutamide Therapy in Preclinical Models of Pten-Deficient Prostate Cancer. | De Velasco, MA., et al. 2021. Cancers (Basel). 13: PMID: 34439133
- New targets of morphine postconditioning protection of the myocardium in ischemia/reperfusion injury: Involvement of HSP90/Akt and C5a/NF-κB. | Tu, RH., et al. 2021. Open Med (Wars). 16: 1552-1563. PMID: 34722891
- Functional proteomics of patient derived head and neck squamous cell carcinoma cells reveal novel applications of trametinib. | Vigoda, M., et al. 2022. Cancer Biol Ther. 23: 310-318. PMID: 35343367
- Lead intoxication-induced exosomes promote autophagy and apoptosis in renal proximal tubule cells by activating the adenosine 5'-monophosphate-activated protein kinase signaling. | Jiang, Q., et al. 2023. Environ Toxicol. 38: 1011-1021. PMID: 36840722
- LYC inhibits the AKT signaling pathway to activate autophagy and ameliorate TGFB-induced renal fibrosis. | Wang, Y., et al. 2024. Autophagy. 20: 1114-1133. PMID: 38037248
- Integrated metabolomics and transcriptomics analyses reveal metabolic responses to TGEV infection in porcine intestinal epithelial cells. | Zhang, S., et al. 2023. J Gen Virol. 104: PMID: 38116760
Inhibitor of:
1600012F09Rik, 2700089E24Rik, 4921501E09Rik, 9430016H08Rik, AI314180, AKAP 100, Akt, Akt1, Akt2, Akt3, ALG-4, AMPK, ANGEL2, ARK5, ATF-7IP, BC057170, BTBD10, C11orf35, C11orf46, C12orf11, C14orf162, C15orf39, C1orf86, C20orf151, C3orf54, C6orf130, CCDC22, Centaurin β5, DCAMKL3, DOCK 4, DPCD, FAM150A, FAM185A, FKHRL1, FYTTD1, GAP-assoc p62, HAX-1, ILKAP, INSL5, IRS-2, KBTBD2, KPI-2, LOC100041208, LOC100041280, LOC728110, LOC728809, MIC2L1, MO25, MST-4, MTMR10, Ndfip1, Nkx-2.5, Nkx-3.1, Olfr585, Olr1620, PAK6, PECI, Pelle, PGs5, PHF14, PHLDA3, PIG11, PITSLRE B, PKA, PKB Kinase, PKC, PLEKHA6, RGD1562043, RUSC1, SAMC, SAMD13, Ser/Thr Protein Kinase, SMG1, SSXB1, Ste20 (sterile 20) Serine/Threonine Kinase (STK), TAPP1, TBC1D3C, TEF-4, TMEM82, TREML6, UEV3, V1RC27, WBSCR9, Zfp781, ZNF714, ZNF763, and ZPR1.Activator of:
ARHGAP39, BC061237, CD2, FNDC3B, FTS, Id4, MAGI-3, PDGF-D, Polycomb, Ribosomal Protein L11, and Thrombospondin 4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GSK 690693, 10 mg | sc-363280 | 10 mg | $255.00 | |||
GSK 690693, 50 mg | sc-363280A | 50 mg | $1071.00 |