Ribosomal Protein L11 Antibody (2A1): sc-293224

Ribosomal Protein L11 Antibody (2A1) is a mouse monoclonal IgG2b kappa light chain antibody that detects Ribosomal Protein L11 (RPL11) of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-RPL11 antibody (2A1) is available as a non-conjugated format. RPL11 plays a crucial role in ribosome assembly and function, essential for protein synthesis in all living cells. RPL11 (2A1) monoclonal antibody localizes to the nucleolus, where RPL11 participates in ribosomal RNA processing and maturation, vital for ribosome formation. RPL11 function remains critical since disruption in ribosome biogenesis can lead to various diseases, including cancer and ribosomopathies. The gene encoding human RPL11 is located on chromosome 1p36.1-p35, and evolutionary conservation across species underscores RPL11′s fundamental role in cellular biology. RPL11 (2A1) antibody serves as an invaluable tool for researchers studying ribosome function and related cellular processes.

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Ribosomal Protein L11 Antibody (2A1) References:

1. Assignment of the L11 ribosomal protein gene (RPL11) to human chromosome 1p36.1-->p35 by in situ hybridization.  |  Graphodatsky, AS., et al. 1999. Cytogenet Cell Genet. 84: 97-8. PMID: 10343117
2. Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway.  |  Zhang, Y., et al. 2003. Mol Cell Biol. 23: 8902-12. PMID: 14612427
3. The mapping of seven intron-containing ribosomal protein genes shows they are unlinked in the human genome.  |  Feo, S., et al. 1992. Genomics. 13: 201-7. PMID: 1577483
4. The primary structure of rat ribosomal proteins: the amino acid sequences of L27a and L28 and corrections in the sequences of S4 and S12.  |  Wool, IG., et al. 1990. Biochim Biophys Acta. 1050: 69-73. PMID: 2207170
5. Physical and functional interaction between ribosomal protein L11 and the tumor suppressor ARF.  |  Dai, MS., et al. 2012. J Biol Chem. 287: 17120-17129. PMID: 22467867
6. Proapoptotic Requirement of Ribosomal Protein L11 in Ribosomal Stress-Challenged Cortical Neurons.  |  Slomnicki, LP., et al. 2018. Mol Neurobiol. 55: 538-553. PMID: 27975169
7. Primary structure of the ribosomal protein gene S6 from Schizosaccharomyces pombe.  |  Gross, T., et al. 1988. Curr Genet. 13: 57-63. PMID: 2834104
8. Ribosomal Protein L11 Selectively Stabilizes a Tertiary Structure of the GTPase Center rRNA Domain.  |  Welty, R., et al. 2020. J Mol Biol. 432: 991-1007. PMID: 31874150
9. The primary structure of the human ribosomal protein S6 derived from a cloned cDNA.  |  Heinze, H., et al. 1988. J Biol Chem. 263: 4139-44. PMID: 3279029
10. Nucleolar Stress Response via Ribosomal Protein L11 Regulates Topoisomerase Inhibitor Sensitivity of P53-Intact Cancers.  |  Ishihara, Y., et al. 2022. Int J Mol Sci. 23: PMID: 36555627
11. Regulation of bacterial stringent response by an evolutionarily conserved ribosomal protein L11 methylation.  |  Walukiewicz, HE., et al. 2024. mBio. 15: e0177324. PMID: 39189746
12. Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs.  |  Frigerio, JM., et al. 1995. Biochim Biophys Acta. 1262: 64-8. PMID: 7772601