Rho T2 Activators
Pancreas transcription factor 1 (PTF1) activators are a group of diverse chemical compounds that indirectly influence the expression of PTF1 through a variety of biochemical and cellular pathways. These compounds, such as retinoic acid and dexamethasone, often interact with cellular differentiation processes, specifically promoting the differentiation of pancreatic progenitor cells into exocrine cells, leading to increased PTF1 expression. Other compounds like forskolin and lithium chloride interact with signaling pathways that support pancreatic cell differentiation and survival. Yet another group, including sodium butyrate and valproic acid, influence PTF1 expression by altering the chromatin structure, which may promote PTF1 transcription.
The mechanisms of action of these compounds demonstrate the complex regulatory network that controls the expression of PTF1. The intricate balance between cellular differentiation, cellular signaling, and chromatin remodeling underlines the breadth of influence these chemicals have on PTF1. However, it's crucial to note that the effect of these compounds on PTF1 expression is indirect, and there is no direct chemical activator for PTF1 known as of now. This complexity further underscores the multifaceted nature of protein activation and regulation in biological systems.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid is a metabolite of vitamin A that is involved in cell growth and differentiation. It can promote the expression of PTF1 by enhancing the differentiation of pancreatic progenitor cells into exocrine cells. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone is a glucocorticoid that can stimulate the differentiation of pancreatic progenitor cells into exocrine cells, indirectly leading to the upregulation of PTF1. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is a plant-derived compound that enhances cyclic AMP (cAMP) levels. Increased cAMP can promote the differentiation of pancreatic progenitor cells, potentially increasing PTF1 expression. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride can inhibit glycogen synthase kinase-3β, a negative regulator of the Wnt/β-catenin signaling pathway, thereby potentially enhancing PTF1 expression. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 18 | |
Sodium butyrate is a short-chain fatty acid that acts as a histone deacetylase inhibitor. By modulating chromatin structure, it can potentially increase PTF1 transcription. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic acid acts as a histone deacetylase inhibitor. It may increase PTF1 expression by promoting chromatin remodeling. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $43.00 $65.00 $200.00 $815.00 | 6 | |
Nicotinamide, a form of vitamin B3, is a PARP inhibitor and has been shown to protect against apoptosis and preserve pancreatic beta cells, potentially leading to increased PTF1 expression. | ||||||
D(+)Glucose, Anhydrous | 50-99-7 | sc-211203 sc-211203B sc-211203A | 250 g 5 kg 1 kg | $37.00 $194.00 $64.00 | 5 | |
High glucose concentrations can stimulate insulin secretion and promote the differentiation of pancreatic beta cells, potentially driving PTF1 expression. | ||||||
Exendin-4 | 141758-74-9 | sc-474611 sc-474611A | 500 µg 1 mg | $143.00 $194.00 | 1 | |
Exendin-4 is a glucagon-like peptide-1 receptor agonist that promotes β-cell proliferation and survival, possibly enhancing PTF1 expression indirectly. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $54.00 $123.00 | 13 | |
Pioglitazone is a PPARγ agonist that can promote adipogenesis and insulin sensitivity. It may indirectly enhance PTF1 expression through its effects on metabolism. | ||||||