Rho T2 Antibody (E-9): sc-518198
- Rho T2 Antibody (E-9) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 400-419 of Rho T2 of human origin
- recommended for detection of Rho T2 of human origin by WB, IP, IF and ELISA
- Anti-Rho T2 Antibody (E-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Rho T2 Antibody (E-9) for WB applications. These reagents are now offered in bundles with Rho T2 Antibody (E-9) (see ordering information below).
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Rho T2 Antibody (E-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects human Rho T2 by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Rho T2 (E-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Rho T2, also known as ARHT2, RASL, or MIRO-2, is a 618 amino acid single-pass type IV membrane protein that plays a crucial role in mitochondrial trafficking as a GTPase. Rho T2 is predominantly expressed in the pancreas, heart, kidney, and skeletal muscle, where Rho T2 influences the anterograde transport of mitochondria. Rho T2 interacts with kinesin-binding proteins such as OIP106 and GRIF-1, facilitating the connection between mitochondria and microtubules, which is essential for proper mitochondrial distribution and function within cells. The presence of two EF-hand domains and two miro domains in Rho T2 contributes to functional versatility, and Rho T2 is encoded by a gene located on human chromosome 16p13.3. The ability of Rho T2 to regulate mitochondrial dynamics is vital for maintaining cellular energy homeostasis and overall cell health, making anti-Rho T2 antibody (E-9) an important tool for researchers studying mitochondrial function and related diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Rho T2 Antibody (E-9) References:
- Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. | Daniels, RJ., et al. 2001. Hum Mol Genet. 10: 339-52. PMID: 11157797
- Atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis. | Fransson, A., et al. 2003. J Biol Chem. 278: 6495-502. PMID: 12482879
- Rho GTPases have diverse effects on the organization of the actin filament system. | Aspenström, P., et al. 2004. Biochem J. 377: 327-37. PMID: 14521508
- Cloning and characterization of the mouse Arht2 gene which encodes a putative atypical GTPase. | Shan, Y., et al. 2004. Cytogenet Genome Res. 106: 91-7. PMID: 15218247
- The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking. | Fransson, S., et al. 2006. Biochem Biophys Res Commun. 344: 500-10. PMID: 16630562
- Bidirectional Ca2+-dependent control of mitochondrial dynamics by the Miro GTPase. | Saotome, M., et al. 2008. Proc Natl Acad Sci U S A. 105: 20728-33. PMID: 19098100
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rho T2 Antibody (E-9) | sc-518198 | 200 µg/ml | $322.00 | |||
Rho T2 Antibody (E-9): m-IgG Fc BP-HRP Bundle | sc-550997 | 200 µg Ab; 10 µg BP | $361.00 | |||
Rho T2 Antibody (E-9): m-IgGκ BP-HRP Bundle | sc-550996 | 200 µg Ab; 40 µg BP | $361.00 | |||
Rho T2 Antibody (E-9): m-IgG1 BP-HRP Bundle | sc-550998 | 200 µg Ab; 20 µg BP | $361.00 | |||
Rho T2 Antibody (E-9) AC | sc-518198 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Rho T2 Antibody (E-9) HRP | sc-518198 HRP | 200 µg/ml | $322.00 | |||
Rho T2 Antibody (E-9) FITC | sc-518198 FITC | 200 µg/ml | $336.00 | |||
Rho T2 Antibody (E-9) PE | sc-518198 PE | 200 µg/ml | $349.00 | |||
Rho T2 Antibody (E-9) Alexa Fluor® 488 | sc-518198 AF488 | 200 µg/ml | $364.00 | |||
Rho T2 Antibody (E-9) Alexa Fluor® 546 | sc-518198 AF546 | 200 µg/ml | $364.00 | |||
Rho T2 Antibody (E-9) Alexa Fluor® 594 | sc-518198 AF594 | 200 µg/ml | $364.00 | |||
Rho T2 Antibody (E-9) Alexa Fluor® 647 | sc-518198 AF647 | 200 µg/ml | $364.00 | |||
Rho T2 Antibody (E-9) Alexa Fluor® 680 | sc-518198 AF680 | 200 µg/ml | $364.00 | |||
Rho T2 Antibody (E-9) Alexa Fluor® 790 | sc-518198 AF790 | 200 µg/ml | $364.00 |