Rho T2 Inhibitors
Compounds that could be classed as RHOT2 inhibitors would be those affecting the function of the RHOT2 protein, which is involved in the tethering and transport of mitochondria along microtubules. Such inhibitors would likely interfere with the GTPase activity of RHOT2 or its ability to interact with microtubules and motor proteins. However, given the specificity of RHOT2's role in mitochondrial dynamics, direct inhibition could potentially lead to a broad impact on cellular energy homeostasis and organelle distribution.
Inhibition could occur through direct binding to RHOT2, altering its conformation and thus its ability to bind GTP, or through the modulation of associated proteins that are critical for RHOT2's function. Additionally, any disruption of the mitochondrial transport system, such as the destabilization of microtubule tracks or the inhibition of motor proteins that interact with RHOT2, could indirectly affect the function of RHOT2. The exact effects of these compounds on RHOT2 and mitochondrial transport would likely depend on a complex interplay between cellular structures, signaling pathways, and the regulation of mitochondrial dynamics.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
A microtubule depolymerizer that can indirectly affect RHOT2 by disrupting the microtubules along which mitochondria are transported. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
A microtubule stabilizer that could alter mitochondrial transport by affecting microtubule dynamics and potentially influencing RHOT2 function. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $259.00 | 41 | |
An inhibitor of mitochondrial complex I, which could impact mitochondrial function and indirectly influence RHOT2 activity. | ||||||
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $55.00 $63.00 $1675.00 $4692.00 | 51 | |
An inhibitor of mitochondrial complex III that could indirectly affect mitochondrial dynamics and thus RHOT2 function. | ||||||
Carbonyl Cyanide m-Chlorophenylhydrazone | 555-60-2 | sc-202984A sc-202984 sc-202984B | 100 mg 250 mg 500 mg | $77.00 $153.00 $240.00 | 8 | |
A mitochondrial uncoupler that can collapse the proton gradient and indirectly affect RHOT2 by altering mitochondrial function. | ||||||
Oligomycin A | 579-13-5 | sc-201551 sc-201551A sc-201551B sc-201551C sc-201551D | 5 mg 25 mg 100 mg 500 mg 1 g | $179.00 $612.00 $1203.00 $5202.00 $9364.00 | 26 | |
An inhibitor of the mitochondrial ATP synthase (complex V) that could indirectly affect RHOT2 by disrupting mitochondrial ATP production. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
An agent that affects microtubule polymerization, potentially altering mitochondrial transport mediated by RHOT2. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
A microtubule-targeting compound that can disrupt microtubule assembly and indirectly affect RHOT2 function. | ||||||
Mdivi-1 | 338967-87-6 | sc-215291 sc-215291B sc-215291A sc-215291C | 5 mg 10 mg 25 mg 50 mg | $67.00 $126.00 $251.00 $465.00 | 13 | |
A selective inhibitor of mitochondrial division that could indirectly influence RHOT2 by affecting mitochondrial fission. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $89.00 | 44 | |
A GTPase inhibitor that can affect dynamin-related processes, potentially altering mitochondrial dynamics involving RHOT2. | ||||||