Molecular structure of Exendin-4, CAS Number: 141758-74-9
Exendin-4 (CAS 141758-74-9)
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Alternate Names:
Exendin-4 is also known as Exenatide.
Application:
Exendin-4 is a 39 amino acid polypeptide, incretin mimetic, GLP-1R agonist, and insulinotropic agent.
CAS Number:
141758-74-9
Purity:
≥97%
Molecular Weight:
4186.57
Molecular Formula:
C184H282N50O60S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Exendin-4 is a 39 amino acid polypeptide and incretin mimetic involved in glucose-dependent enhancement of insulin secretion. It also promotes reduction of hyperglycemia, glucose-dependent suppression of inappropriately high glucagon secretion, slowing of gastric emptying, and reduction of food intake, often with body weight reduction or blunting of weight gain. Exendin-4 is a GLP-1R agonist, has a long half-life, and performs as an insulinotropic agent. It was originally sourced from the Gila monster lizard, Heloderma suspectum.
Exendin-4 (CAS 141758-74-9) References
- Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats. | Xu, G., et al. 1999. Diabetes. 48: 2270-6. PMID: 10580413
- Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas. | Eng, J., et al. 1992. J Biol Chem. 267: 7402-5. PMID: 1313797
- Exenatide treatment exerts anxiolytic- and antidepressant-like effects and reverses neuropathy in a mouse model of type-2 diabetes. | Komsuoglu Celikyurt, I., et al. 2014. Med Sci Monit Basic Res. 20: 112-7. PMID: 25076419
- Exenatide alleviates mitochondrial dysfunction and cognitive impairment in the 5×FAD mouse model of Alzheimer's disease. | An, J., et al. 2019. Behav Brain Res. 370: 111932. PMID: 31082410
- Exenatide Reduces Graft Injury in a Rat Transplantation Model Using Kidneys Donated after Cardiac Death. | Hua Yang, ., et al. 2019. Transplant Proc. 51: 2116-2123. PMID: 31303407
- Pharmacokinetics of Exenatide in nonhuman primates following its administration in the form of sustained-release PT320 and Bydureon. | Li, Y., et al. 2019. Sci Rep. 9: 17208. PMID: 31748513
- Exenatide ameliorates experimental non-alcoholic fatty liver in rats via suppression of toll-like receptor 4/NFκB signaling: Comparison to metformin. | Saad, ZA., et al. 2020. Life Sci. 253: 117725. PMID: 32348835
- Exenatide improves random-pattern skin flap survival via TFE3 mediated autophagy augment. | Li, J., et al. 2021. J Cell Physiol. 236: 3641-3659. PMID: 33044023
- Exenatide Attenuates Non-Alcoholic Steatohepatitis by Inhibiting the Pyroptosis Signaling Pathway. | Liu, Y., et al. 2021. Front Endocrinol (Lausanne). 12: 663039. PMID: 33953700
- Exenatide ameliorates hydrogen peroxide-induced pancreatic β-cell apoptosis through regulation of METTL3-mediated m6A methylation. | Zhou, S., et al. 2022. Eur J Pharmacol. 924: 174960. PMID: 35436474
- Characterization of the physicochemical interactions between exenatide and two intestinal permeation enhancers: Sodium caprate (C10) and salcaprozate sodium (SNAC). | Twarog, C., et al. 2022. Int J Pharm. 626: 122131. PMID: 36028084
- Exenatide increases CTRP3 gene expression in adipose cells by inhibiting adipogenesis and induces apoptosis. | Koldemir Gündüz, M., et al. 2022. Toxicol In Vitro. 85: 105479. PMID: 36152787
- Exenatide regulates Th17/Treg balance via PI3K/Akt/FoxO1 pathway in db/db mice. | Xu, Q., et al. 2022. Mol Med. 28: 144. PMID: 36463128
Inhibitor of:
Angptl5, APPL2, C20orf117, CDKAL1, cHMGCS, CTRP7, EG329055, GADD 153, GCG, GIP, GPR119, granuphilin, Olr1591, Peptide YY3, PGC-1α, SLC30, SSTR3, TUSC5, ZnT-6, and ZnT-8.Activator of:
ACBD4, BRIDGE-1, CEACAM6, CTRP4, FAS, GIPR, Gl Syn, GLP-1R, GLP1, Glucagon Receptor, INSL5, Insulin, Insulinm Solution, Pax-4, Reg Iβ, Rho T2, Rtl1, TIP47, and YSK1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Exendin-4, 500 µg | sc-474611 | 500 µg | $143.00 | |||
Exendin-4, 1 mg | sc-474611A | 1 mg | $194.00 |