RGS4 Activators
RGS4, or Regulator of G protein Signaling 4, plays a crucial role in modulating intracellular signaling pathways by acting as a GTPase-activating protein (GAP) for heterotrimeric G proteins. Its primary function revolves around the regulation of G protein-coupled receptor (GPCR) signaling, which is pivotal in controlling various cellular processes such as neurotransmission, hormone secretion, and immune responses. Specifically, RGS4 functions by accelerating the hydrolysis of GTP bound to the Gα subunit of G proteins, thereby facilitating the termination of GPCR-mediated signaling cascades. This activity ultimately helps in maintaining cellular homeostasis and disrupting aberrant signaling events.
The activation of RGS4 involves intricate molecular mechanisms that often depend on its interaction with other cellular components. One of the primary modes of activation involves the binding of RGS4 to activated Gα subunits of G proteins, particularly those coupled to GPCRs. This binding enhances the GAP activity of RGS4, leading to the accelerated hydrolysis of GTP bound to Gα subunits and subsequent attenuation of downstream signaling pathways. Additionally, post-translational modifications such as phosphorylation and palmitoylation have been implicated in regulating the activity and subcellular localization of RGS4, further modulating its function. Moreover, various intracellular signaling molecules and second messengers may also regulate RGS4 activity through allosteric mechanisms, highlighting the complex regulatory network governing its activation. Overall, the activation of RGS4 represents a critical checkpoint in the regulation of GPCR-mediated signaling pathways, with profound implications for cellular physiology and pathophysiology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels, which can enhance PKA activity. PKA can phosphorylate various targets in GPCR signaling, potentially activating RGS4 activity indirectly. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine inhibits phosphodiesterases, leading to increased cAMP levels. This can enhance PKA activity, which may indirectly influence RGS4 activity through phosphorylation of components in the GPCR pathway. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4 (PDE4), leading to increased cAMP and subsequently enhanced PKA activity. This may indirectly activate RGS4 activity by altering GPCR signaling dynamics. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a non-selective agonist of beta-adrenergic receptors, leading to increased cAMP and PKA activation. This can indirectly activate RGS4 function in the context of GPCR signaling. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
This compound modulate GPCR signaling pathways. This modulation may indirectly activate RGS4 activity through altered G protein signaling dynamics. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $33.00 $47.00 $294.00 $561.00 $1020.00 $2550.00 $4590.00 | 1 | |
Adenosine acts on its GPCR receptors to modulate cellular signaling. This could indirectly affect RGS4 activity by activating G protein-coupled signaling pathways. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $92.00 $277.00 $969.00 | 7 | |
Histamine, through its GPCR receptors, modulates various signaling pathways. This modulation can indirectly activate RGS4 activity by altering G protein-coupled signaling dynamics. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin, the active component in chili peppers, can influence GPCR signaling. This might indirectly activate RGS4 activity through changes in G protein-coupled signaling pathways. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
Prostaglandin E2, acting through its GPCR receptors, modulates various signaling pathways. This could indirectly activate RGS4 activity by altering G protein signaling dynamics. | ||||||
L-Noradrenaline | 51-41-2 | sc-357366 sc-357366A | 1 g 5 g | $320.00 $475.00 | 3 | |
Norepinephrine, acting on adrenergic receptors, influences GPCR signaling. This can indirectly activate RGS4 function in these signaling pathways. | ||||||