RGS4 Antibody (H-12): sc-398348

RGS4 Antibody (H-12) is a mouse monoclonal IgM antibody that detects RGS4 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-RGS4 antibody (H-12) is available as the non-conjugated form. RGS4 plays a crucial role in regulating G protein signaling pathways, which are essential for transmitting signals from various receptors on the cell surface to intracellular targets. This regulation is vital for numerous physiological processes, including neurotransmission, cardiovascular function, and immune responses. RGS4 specifically acts as a GTPase-activating protein (GAP) for certain G protein alpha subunits, such as Gαi, Gαo, and Gαt, thereby accelerating the hydrolysis of GTP to GDP and promoting the inactivation of these signaling pathways. By modulating G protein activity, RGS4 helps maintain cellular homeostasis and ensures appropriate signal termination, preventing overstimulation that could lead to pathological conditions. RGS4′s interaction with specific Gα isoforms highlights its importance in fine-tuning signal transduction and underscores its potential as a therapeutic target in diseases where G protein signaling is dysregulated.

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RGS4 Antibody (H-12) References:

1. Different beta-subunits determine G-protein interaction with transmembrane receptors.  |  Kleuss, C., et al. 1992. Nature. 358: 424-6. PMID: 1322501
2. Selective tissue distribution of G protein gamma subunits, including a new form of the gamma subunits identified by cDNA cloning.  |  Cali, JJ., et al. 1992. J Biol Chem. 267: 24023-7. PMID: 1385432
3. Diversity among the beta subunits of heterotrimeric GTP-binding proteins: characterization of a novel beta-subunit cDNA.  |  von Weizsäcker, E., et al. 1992. Biochem Biophys Res Commun. 183: 350-6. PMID: 1543505
4. Gustducin is a taste-cell-specific G protein closely related to the transducins.  |  McLaughlin, SK., et al. 1992. Nature. 357: 563-9. PMID: 1608467
5. Diversity of G proteins in signal transduction.  |  Simon, MI., et al. 1991. Science. 252: 802-8. PMID: 1902986
6. A gene-based review of RGS4 as a putative risk gene for psychiatric illness.  |  Schwarz, E. 2018. Am J Med Genet B Neuropsychiatr Genet. 177: 267-273. PMID: 28544755
7. The therapeutic potential of targeting cardiac RGS4.  |  Del Calvo, G., et al. 2023. Ther Adv Cardiovasc Dis. 17: 17539447231199350. PMID: 37724539
8. RGS4 Actions in Mouse Prefrontal Cortex Modulate Behavioral and Transcriptomic Responses to Chronic Stress and Ketamine.  |  Mitsi, V., et al. 2024. Mol Pharmacol. 105: 272-285. PMID: 38351270
9. RGS4 controls airway hyperresponsiveness through GAP-independent mechanisms.  |  Joshi, IV., et al. 2024. J Biol Chem. 300: 107127. PMID: 38432633
10. Structural elements of G alpha subunits that interact with G beta gamma, receptors, and effectors.  |  Conklin, BR. and Bourne, HR. 1993. Cell. 73: 631-41. PMID: 8388779
11. RGS family members: GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.  |  Watson, N., et al. 1996. Nature. 383: 172-5. PMID: 8774882
12. RGS10 is a selective activator of G alpha i GTPase activity.  |  Hunt, TW., et al. 1996. Nature. 383: 175-7. PMID: 8774883

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-RGS4 Antibody (H-12) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-RGS4 Antibody (H-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

RGS4 Antibody (H-12) Specifications

Alternate Product Name: RGS4

Product Clone Name: H-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 182-205

Epitope Target: RGS4

Epitope Species: human

Product Reactivity/Detection: RGS4

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for RGS4 Antibody (H-12): P: Blocking Peptide