RGS14 Activators
RGS14 Activators encompass a range of chemicals that indirectly influence the activity of the RGS14 protein. These chemicals primarily alter the signaling pathways that RGS14 is involved in, rather than directly activating the protein. These chemicals include inhibitors of G-protein signaling like Pertussis Toxin, Gallein, YM-254890, NF449, and M119. They also include chemicals that affect the GDP/GTP state of G-proteins, such as GDP and GTPγS, and chemicals that alter cAMP levels and cAMP-mediated signaling, like Forskolin, IBMX, Rolipram, KT5720, and H89.
The indirect activation of RGS14 by these chemicals occurs through a variety of mechanisms, largely by influencing the cellular signaling pathways that RGS14 participates in. For instance, chemicals that alter G-protein signaling can influence RGS14's G-protein regulatory function, as RGS14 is known to interact with G-proteins and their subunits. Similarly, chemicals that affect the GDP/GTP state of G-proteins can indirectly affect RGS14's activity, as the G-protein's GDP/GTP state is crucial for RGS14's regulation of G-protein signaling. Moreover, chemicals that influence cAMP levels and cAMP-mediated signaling can also have an indirect impact on RGS14, as RGS14 is known to be involved in cAMP-mediated signaling pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Pertussis Toxin (islet-activating protein) | 70323-44-3 | sc-200837 | 50 µg | $451.00 | 3 | |
Pertussis Toxin can deactivate G-proteins by ADP-ribosylation, thereby affecting RGS14's G-protein regulatory function. | ||||||
Corilagin | 23094-69-1 | sc-211135 | 5 mg | $280.00 | 1 | |
Corilagin is a Gβγ signaling inhibitor. As RGS14 interacts with Gβγ subunits, gallein can indirectly influence RGS14 activity. | ||||||
YM 254890 | 568580-02-9 | sc-507356 | 1 mg | $510.00 | ||
YM-254890 is a selective Gq inhibitor. As RGS14 can interact with activated Gq, this would indirectly influence RGS14. | ||||||
Guanosine 5′-O-(3-thiotriphosphate) tetralithium salt | 94825-44-2 | sc-202639 | 10 mg | $465.00 | ||
GTPγS is a non-hydrolyzable GTP analogue that can keep G-proteins in an active state, indirectly affecting RGS14's regulatory function. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing cAMP levels, which can indirectly interact with RGS14's role in cAMP-mediated signaling. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-selective phosphodiesterase inhibitor that raises intracellular cAMP levels, potentially influencing RGS14. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram selectively inhibits PDE4, thus increasing intracellular cAMP levels and potentially affecting RGS14. | ||||||
NF 449 | 389142-38-5 | sc-203159 | 10 mg | $314.00 | 5 | |
NF449 is a potent Gαs-selective antagonist, which could influence RGS14's G-protein regulatory function. | ||||||
BI 78D3 | 883065-90-5 | sc-203840 sc-203840A | 10 mg 50 mg | $204.00 $810.00 | 2 | |
BI 78D3 is a selective Gβγ inhibitor, which could affect RGS14's interaction with Gβγ subunits. | ||||||
KT 5720 | 108068-98-0 | sc-3538 sc-3538A sc-3538B | 50 µg 100 µg 500 µg | $138.00 $220.00 $972.00 | 47 | |
KT5720 is a potent and selective inhibitor of protein kinase A (PKA), which could influence cAMP-mediated signaling involving RGS14. | ||||||