Corilagin (CAS 23094-69-1)
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Corilagin is a chemical compound that functions as a potent antioxidant and anti-inflammatory agent. It exerts its mechanism of action by inhibiting the activity of various enzymes involved in the inflammatory response, such as cyclooxygenase and lipoxygenase. Corilagin may modulate the production of pro-inflammatory cytokines, thereby reducing the inflammatory cascade. At the molecular level, it interacts with specific signaling pathways involved in the regulation of inflammation, including the nuclear factor-kappa B (NF-κB) pathway. This interaction ultimately leads to the downregulation of inflammatory gene expression. Corilagin used to possess antimicrobial properties, inhibiting the growth of various pathogens by disrupting their cellular processes. Corilagin plays a role in modulating inflammatory and oxidative processes at the molecular and cellular levels, making it useful for investigating these pathways in experimental applications.
Corilagin (CAS 23094-69-1) References
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- Modulation of PAI-1 and tPA activity and thrombolytic effects of corilagin. | Shen, ZQ., et al. 2003. Planta Med. 69: 1109-12. PMID: 14750026
- Corilagin inhibits the double strand break-triggered NF-kappaB pathway in irradiated microglial cells. | Dong, XR., et al. 2010. Int J Mol Med. 25: 531-6. PMID: 20198301
- Corilagin, a promising medicinal herbal agent. | Li, X., et al. 2018. Biomed Pharmacother. 99: 43-50. PMID: 29324311
- Corilagin alleviates acetaminophen-induced hepatotoxicity via enhancing the AMPK/GSK3β-Nrf2 signaling pathway. | Lv, H., et al. 2019. Cell Commun Signal. 17: 2. PMID: 30630510
- Corilagin in Cancer: A Critical Evaluation of Anticancer Activities and Molecular Mechanisms. | Gupta, A., et al. 2019. Molecules. 24: PMID: 31546767
- Corilagin prevents SARS-CoV-2 infection by targeting RBD-ACE2 binding. | Yang, LJ., et al. 2021. Phytomedicine. 87: 153591. PMID: 34029937
- Corilagin ameliorates atherosclerosis by regulating MMP-1, -2, and -9 expression in vitro and in vivo. | Tao, Y., et al. 2021. Eur J Pharmacol. 906: 174200. PMID: 34062170
- Anti-proliferation and anti-inflammation effects of corilagin in rheumatoid arthritis by downregulating NF-κB and MAPK signaling pathways. | Shen, Y., et al. 2022. J Ethnopharmacol. 284: 114791. PMID: 34737112
- Corilagin induces apoptosis and inhibits autophagy of HL‑60 cells by regulating miR‑451/HMGB1 axis. | Jia, S., et al. 2022. Mol Med Rep. 25: PMID: 34850958
- Corilagin Ameliorates Con A-Induced Hepatic Injury by Restricting M1 Macrophage Polarization. | Yan, F., et al. 2021. Front Immunol. 12: 807509. PMID: 35095894
- Corilagin Restrains NLRP3 Inflammasome Activation and Pyroptosis through the ROS/TXNIP/NLRP3 Pathway to Prevent Inflammation. | Luo, T., et al. 2022. Oxid Med Cell Longev. 2022: 1652244. PMID: 36299604
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Corilagin, 5 mg | sc-211135 | 5 mg | $280.00 |