RFX3 Inhibitors
Chemical inhibitors of RFX3 can target various signaling pathways that are critical for its functional activity. Staurosporine, a non-selective protein kinase inhibitor, can inhibit RFX3 by interfering with the phosphorylation events necessary for its activity. Similarly, LY294002 and Wortmannin are both inhibitors of PI3K, a key player in multiple signaling pathways, including those regulating transcription factors. By inhibiting PI3K, these chemicals can reduce the activation of downstream targets necessary for RFX3 activity, effectively leading to its functional inhibition. PD 98059 and U0126 are inhibitors of MEK, which is an upstream regulator of the MAPK/ERK pathway. By preventing MEK from activating ERK, these inhibitors disrupt the phosphorylation and activation of ERK, which is necessary for RFX3 function. SP600125, an inhibitor of JNK, and SB203580, an inhibitor of p38 MAP kinase, both target kinases involved in stress and cytokine signaling; their inhibition can disrupt regulatory pathways that control the activity of RFX3.
Go6983 and GF109203X, both inhibitors of protein kinase C (PKC), along with BIM-1, can prevent the PKC-mediated phosphorylation processes that contribute to the activity of RFX3. SL327, another MEK inhibitor, functions similarly to PD 98059 and U0126 by preventing the activation of ERK, thereby hindering the phosphorylation-dependent activity of RFX3. Lastly, H-89 targets protein kinase A (PKA), which phosphorylates various proteins, including transcription factors. By inhibiting PKA, H-89 disrupts regulatory processes that are essential for the functional activity of RFX3.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent, non-selective inhibitor of protein kinases. RFX3 is known to be regulated by phosphorylation, thus staurosporine can inhibit RFX3 by preventing its necessary phosphorylation events, which are crucial for its functional activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor. PI3K signaling is integral for the regulation of numerous transcription factors. By inhibiting PI3K, LY294002 reduces the activation of downstream targets that may be essential for RFX3 functional activity, thus indirectly inhibiting RFX3. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD 98059 is an inhibitor of MEK, which is upstream of the MAPK/ERK pathway. RFX3 activity can be regulated by the MAPK/ERK pathway, and inhibiting MEK with PD 98059 would prevent the phosphorylation and activation of ERK, thus indirectly inhibiting RFX3. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK, a kinase that can influence transcription factors. By inhibiting JNK, SP600125 could disrupt regulatory pathways that control the activity of RFX3, leading to its functional inhibition. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a selective inhibitor of p38 MAP kinase. By inhibiting p38, which is involved in stress and cytokine signaling, SB203580 can indirectly inhibit RFX3 by disrupting the pathways that activate it. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent inhibitor of PI3K. By inhibiting PI3K, wortmannin can disrupt pathways that are necessary for the activation and function of RFX3, leading to its inhibition. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $103.00 $293.00 $465.00 | 15 | |
Go6983 is a protein kinase C (PKC) inhibitor. Since PKC can phosphorylate a wide range of target proteins, including transcription factors, Go6983 can indirectly inhibit RFX3 by preventing PKC-mediated phosphorylation processes that would otherwise contribute to RFX3's activity. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK1/2, which are upstream regulators of the ERK pathway. By inhibiting MEK1/2, U0126 prevents the activation of ERK, which could be necessary for the proper function of RFX3, thus resulting in its inhibition. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
GF109203X is another inhibitor of protein kinase C (PKC). By inhibiting PKC, it prevents the activation of pathways that may be necessary for the phosphorylation and activation of RFX3, leading to its functional inhibition. | ||||||
SL-327 | 305350-87-2 | sc-200685 sc-200685A | 1 mg 10 mg | $107.00 $332.00 | 7 | |
SL327 is an inhibitor of MEK, which is involved in the MAPK/ERK pathway. By inhibiting MEK, SL327 prevents the activation of ERK, which could be necessary for the phosphorylation and subsequent activity of RFX3, thus inhibiting its function. | ||||||