REGIIIα Inhibitors
REGIIIα inhibitors are a class of chemical compounds specifically designed to target and inhibit the function of REGIIIα, a member of the regenerating gene (REG) family of proteins. REGIIIα, also known as HIP/PAP (Hepatocarcinoma-Intestine-Pancreas/Pancreatitis-Associated Protein), is primarily expressed in the pancreas and the gastrointestinal tract. It plays a crucial role in maintaining gut homeostasis and the innate immune response, particularly by binding to bacterial cell walls and promoting bacterial clearance. REGIIIα functions as a C-type lectin, which allows it to bind to peptidoglycan, a key component of bacterial cell walls, helping to modulate the interaction between host cells and the microbial environment. Inhibitors of REGIIIα typically work by interfering with its ability to bind to bacterial cell walls or by disrupting its structural integrity, preventing it from exerting its normal biological function.
The inhibition of REGIIIα can lead to significant changes in how the body responds to microbial presence, particularly in the gastrointestinal tract. By blocking the protein's ability to bind to bacterial components, REGIIIα inhibitors disrupt the antimicrobial barrier that it provides, which can affect the equilibrium of host-microbe interactions in the gut. These inhibitors are valuable tools for researchers looking to understand the detailed function of REGIIIα in immune modulation and its role in maintaining gut microbiota balance. Additionally, studying REGIIIα inhibitors allows scientists to investigate how this protein contributes to epithelial defense mechanisms and gut barrier integrity. By examining the effects of inhibiting REGIIIα, researchers can explore its broader regulatory roles in the immune system and its interactions with bacterial populations, deepening the understanding of host-pathogen interactions and the molecular mechanisms that underpin gut health and immune defense.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin may downregulate REGIIIα expression by suppressing the activation of the NF-κB pathway, which is directly involved in the induction of REGIIIα in response to bacterial antigens. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol could decrease the expression of REGIIIα by hindering the SIRT1 pathway, which has been implicated in controlling the immune response within the intestinal mucosa and could play a role in the synthesis of antimicrobial peptides such as REGIIIα. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin Gallate might inhibit the transcription of REGIIIα by attenuating the activity of the STAT3 signaling pathway, known to be critical in the inflammatory response and in the defense against pathogens. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin could reduce the expression of REGIIIα by inhibiting the JAK-STAT signaling pathway, which may be involved in the regulation of genes associated with the immune response in the gut. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate might downregulate REGIIIα expression by altering the chromatin structure around the REGIIIα gene, leading to tighter packaging and less accessibility for transcription factors. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
DL-Sulforaphane may suppress REGIIIα expression by reducing oxidative stress, which can lead to a decrease in the signaling molecules that prompt REGIIIα synthesis in Paneth cells. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid might decrease REGIIIα expression by attenuating the differentiation of immune cells that are responsible for the secretion of cytokines, which stimulate REGIIIα production. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Cholecalciferol may inhibit the production of REGIIIα by downregulating the expression of pro-inflammatory cytokines that signal through the vitamin D receptor, which may be involved in REGIIIα gene transcription. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone could suppress the expression of REGIIIα by reducing the availability of transcription factors such as AP-1, which are necessary for the induction of REGIIIα following microbial recognition. | ||||||
Hydrocortisone | 50-23-7 | sc-300810 | 5 g | $102.00 | 6 | |
Hydrocortisone may decrease REGIIIα expression by attenuating the immune response, particularly the release of cytokines that promote REGIIIα synthesis in response to gut microbiota. | ||||||