Reg II Inhibitors
Reg II, short for Regenerating islet-derived protein II, belongs to the regenerating gene (Reg) family of proteins. This family is renowned for its potential role in cellular proliferation and differentiation, particularly within the pancreatic islets. The Reg family was first identified in regenerating pancreatic islets, hence their name. These proteins play a pivotal role in the regeneration and growth of pancreatic islet beta cells. Reg II, like other members of its family, has been implicated in various cellular processes, including anti-apoptotic activity and the facilitation of cell survival. Its presence and function have been observed in the pancreas, gastrointestinal tract, and several other tissues, illustrating its versatile role in cellular maintenance and survival.
Inhibitors targeting Reg II are designed to modulate the activity of this protein. Such inhibitors can interfere with the protein's function, either by impeding its interaction with other cellular components or by affecting its structural conformation. Given the role of Reg II in cell survival and proliferation, its inhibitors can be of great interest in understanding the molecular underpinnings of these processes. By regulating the activity of Reg II, these inhibitors provide a means to delve deeper into the intricate cellular pathways in which this protein is involved. Moreover, they can be instrumental in studying the broader Reg family and elucidating the shared and unique functions of its members. The development and study of Reg II inhibitors are essential for a comprehensive understanding of cellular regeneration processes and the molecular mechanisms that underpin them.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Exendin-3 (9-39) | 133514-43-9 | sc-364387 | 500 µg | $428.00 | 6 | |
This peptide antagonizes GLP-1 receptor. Since GLP-1 affects pancreatic β-cell function, it might indirectly affect Reg II expression. | ||||||
Diazoxide | 364-98-7 | sc-200980 | 1 g | $300.00 | 5 | |
An ATP-sensitive potassium channel opener which might have indirect effects on islet cell function and hence Reg II. | ||||||
Somatostatin | 51110-01-1 | sc-391009 sc-391009A | 1 mg 5 mg | $114.00 $536.00 | 9 | |
A hormone that inhibits the secretion of many other hormones, might have indirect effects on Reg II via pancreatic hormone regulation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
An mTOR inhibitor, affecting cell growth and proliferation, which could indirectly influence Reg II. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
A calcium channel blocker which might influence cell signaling in the pancreas and potentially affect Reg II. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
A PI3K inhibitor which can affect various cell signaling pathways, potentially influencing Reg II. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
An ERK pathway inhibitor. Since ERK pathway can be involved in cell growth, it might affect Reg II. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
A JNK inhibitor which might influence cell stress responses and indirectly Reg II. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A PI3K inhibitor which can affect various cell signaling pathways, potentially influencing Reg II. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
A p38 MAPK inhibitor, affecting cellular stress pathways, potentially influencing Reg II. | ||||||