Somatostatin (CAS 51110-01-1)
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Somatostatin is a 14-amino acid peptide that functions as an inhibitory hormone and affects neurotransmission and cell proliferation through interaction with G proteint-coupled somatostatin receptors. It is expressed in the central and peripheral nervous systems and parts of the digestive system. In the anterior pituitary gland, somatostatin inhibits the release of growth hormone and thyroid-stimulating hormones. Somatostatin suppresses the release of the gastrointestinal hormones gastrin, cholecystokinin, secretin, motilin, vasoactive intestinal peptide, gastric inhibitory polypeptide and enteroglucagon, and of the pancreatic hormones insulin and glucagon. Somatostatin is homologous to cortistatin. Somatostatin is an inhibitor of Calcium Channel Protein.
Somatostatin (CAS 51110-01-1) References
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- Somatostatin signaling and the regulation of growth and metabolism in fish. | Klein, SE. and Sheridan, MA. 2008. Mol Cell Endocrinol. 286: 148-54. PMID: 17919810
- Somatostatin secretion and action in the regulation of growth hormone secretion. | Frohman, LA., et al. 1990. Metabolism. 39: 43-5. PMID: 1976219
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- The use of somatostatin and its analogs in the treatment of surgical disorders. | Mulvihill, S., et al. 1986. Surgery. 100: 467-76. PMID: 2874618
- Somatostatin and octreotide: literature review and description of therapeutic activity in pancreatic neoplasia. | Longnecker, SM. 1988. Drug Intell Clin Pharm. 22: 99-106. PMID: 2894968
- The inhibitory effect of somatostatin on gastric motility in Suncus murinus. | Sekiya, H., et al. 2020. J Smooth Muscle Res. 56: 69-81. PMID: 33473062
- Somatostatin and Somatostatin-Containing Interneurons-From Plasticity to Pathology. | Liguz-Lecznar, M., et al. 2022. Biomolecules. 12: PMID: 35204812
- Somatostatin modulates voltage-dependent Ca2+ channels in GH3 cells via a specific G(o) splice variant. | Kleuss, C. 1995. Ciba Found Symp. 190: 171-82; discussion 182-6. PMID: 7587646
- [Vasopressin, somatostatin and digestive hemorrhages in portal hypertension: the end of the tunnel?]. | Calès, P. 1994. Gastroenterol Clin Biol. 18: 739-42. PMID: 7875444
- Somatostatin and somatostatin analogues: pharmacokinetics and pharmacodynamic effects. | Harris, AG. 1994. Gut. 35: S1-4. PMID: 7911441
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Somatostatin, 1 mg | sc-391009 | 1 mg | $112.00 | |||
Somatostatin, 5 mg | sc-391009A | 5 mg | $525.00 |